Erzsebet Kokovay
Overview
Explore the profile of Erzsebet Kokovay including associated specialties, affiliations and a list of published articles.
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29
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1491
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Recent Articles
1.
Chen Q, Aguirre L, Zhao H, Borrego F, de Rojas I, Su L, et al.
medRxiv
. 2023 Nov;
PMID: 37961425
Introduction: The APOE gene is the strongest genetic risk factor for late-onset Alzheimer's Disease (LOAD). However, the gene regulatory mechanisms at this locus have not been fully characterized. Methods: To...
2.
Dietert K, Mahesula S, Hegde S, Verschelde J, Reed P, Sprague S, et al.
Stem Cells
. 2023 May;
41(6):570-577.
PMID: 37186298
After ischemia, cells in the brain parenchyma upregulate stromal derived factor 1 (SDF1), driving chemokine receptor CXCR4-mediated migration of adult neural stem cells to the ischemic injury. We discovered a...
3.
Mendiola A, Church K, Cardona S, Vanegas D, Garcia S, Macklin W, et al.
J Neurochem
. 2022 May;
162(5):430-443.
PMID: 35560167
Microglia have been implicated in multiple sclerosis (MS) pathogenesis. The fractalkine receptor CX3CR1 limits the activation of pathogenic microglia and the human polymorphic CX3CR1 (hCX3CR1 ) variant increases disease progression...
4.
Kosti A, Barreiro R, Guardia G, Ostadrahimi S, Kokovay E, Pertsemlidis A, et al.
Cancers (Basel)
. 2021 Jan;
13(2).
PMID: 33466745
Tumor suppressor microRNAs (miRNAs) have been explored as agents to target cancer stem cells. Most strategies use a single miRNA mimic and present many disadvantages, such as the amount of...
5.
Kosti A, de Araujo P, Li W, Guardia G, Chiou J, Yi C, et al.
Genome Biol
. 2020 Aug;
21(1):195.
PMID: 32762776
Background: RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation...
6.
Cutler R, Kokovay E
Curr Opin Pharmacol
. 2019 Nov;
50:1-8.
PMID: 31756641
Neural stem cells exist in specialized regions of the brain and have the capacity to give rise to neurons and glia over the lifespan. The process of giving rise to...
7.
Katsimpardi L, Kuperwasser N, Camus C, Moigneu C, Chiche A, Tolle V, et al.
Aging Cell
. 2019 Oct;
19(1):e13038.
PMID: 31637864
Aging is a negative regulator of general homeostasis, tissue function, and regeneration. Changes in organismal energy levels and physiology, through systemic manipulations such as calorie restriction and young blood infusion,...
8.
Kosti A, Du L, Shivram H, Qiao M, Burns S, Garcia J, et al.
Mol Cancer Res
. 2019 Oct;
18(1):68-78.
PMID: 31624087
13--retinoic acid (RA) is typically used in postremission maintenance therapy in patients with neuroblastoma. However, side effects and recurrence are often observed. We investigated the use of miRNAs as a...
9.
Velasco M, Kosti A, Guardia G, Santos M, Tegge A, Qiao M, et al.
RNA
. 2019 Apr;
25(7):768-782.
PMID: 31004009
RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a...
10.
Apple D, Mahesula S, Fonseca R, Zhu C, Kokovay E
Aging (Albany NY)
. 2019 Jan;
11(1):115-126.
PMID: 30622221
The brain can generate new neurons from neural stem cells throughout life. However, the capacity for neurogenesis declines with age, reducing the potential for learning and repair. We explored the...