Antagonism Between the RNA-binding Protein Musashi1 and MiR-137 and Its Potential Impact on Neurogenesis and Glioblastoma Development

Overview

Journal RNA

Specialty Molecular Biology

Date 2019 Apr 21

PMID 31004009

Citations 19

Authors

Mitzli X Velasco

Adam Kosti

Gabriela D A Guardia

Marcia C Santos

Allison Tegge

Mei Qiao

Bruna R S Correa

Greco Hernandez

Erzsebet Kokovay

Pedro A F Galante

Luiz O F Penalva

Affiliations

Soon will be listed here.

Abstract

RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposite expression patterns and functions, and is repressed by miR-137. Msi1 is a stem-cell protein implicated in self-renewal while miR-137 functions as a proneuronal differentiation miRNA. In gliomas, miR-137 functions as a tumor suppressor while Msi1 is a prooncogenic factor. We suggest that the balance between Msi1 and miR-137 is a key determinant in cell fate decisions and disruption of this balance could contribute to neurodegenerative diseases and glioma development. Genomic analyses revealed that Msi1 and miR-137 share 141 target genes associated with differentiation, development, and morphogenesis. Initial results pointed out that these two regulators have an opposite impact on the expression of their target genes. Therefore, we propose an antagonistic model in which this network of shared targets could be either repressed by miR-137 or activated by Msi1, leading to different outcomes (self-renewal, proliferation, tumorigenesis).

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