Ernesto Lopes Pinheiro-Junior
Overview
Explore the profile of Ernesto Lopes Pinheiro-Junior including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
242
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Recent Articles
1.
Pinheiro-Junior E, Alirahimi E, Peigneur S, Isensee J, Schiffmann S, Erkoc P, et al.
BMC Biol
. 2024 Jul;
22(1):164.
PMID: 39075558
Background: The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the only crustacean...
2.
Joukhan A, Kononenko V, Bele T, Dolenc M, Peigneur S, Pinheiro-Junior E, et al.
Mar Drugs
. 2024 Apr;
22(4).
PMID: 38667764
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. In this study, we aimed to investigate the potential...
3.
Gubic S, Montalbano A, Sala C, Becchetti A, Hendrickx L, Van Theemsche K, et al.
Eur J Med Chem
. 2023 Jul;
259:115561.
PMID: 37454520
Voltage-gated potassium channel K1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca homeostasis. Here, we present the structure-activity relationship, K1.3 inhibition,...
4.
Gubic S, Hendrickx L, Shi X, Toplak Z, Mozina S, Van Theemsche K, et al.
Cancers (Basel)
. 2023 Jun;
15(11).
PMID: 37297027
In the original publication [...].
5.
Depuydt A, Patel P, Toplak Z, Bhat C, Voracova M, Etelainen I, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834837
T-type calcium (Ca3) channels are involved in cardiac automaticity, development, and excitation-contraction coupling in normal cardiac myocytes. Their functional role becomes more pronounced in the process of pathological cardiac hypertrophy...
6.
Kalina R, Kasheverov I, Koshelev S, Sintsova O, Peigneur S, Pinheiro-Junior E, et al.
Toxins (Basel)
. 2022 Oct;
14(10).
PMID: 36287966
The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters. Here, four APETx-like toxins,...
7.
Kuzmenkov A, Peigneur S, Nasburg J, Mineev K, Nikolaev M, Pinheiro-Junior E, et al.
Front Pharmacol
. 2022 Oct;
13:977440.
PMID: 36188602
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca-activated potassium channels (K2). However, published pharmacological and structural data remain controversial. Here, we investigated the...
8.
Gubic S, Toplak Z, Shi X, Dernovsek J, Hendrickx L, Pinheiro-Junior E, et al.
Pharmaceutics
. 2022 Sep;
14(9).
PMID: 36145712
Expression of the voltage-gated potassium channel K10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A...
9.
Cordeiro F, Amorim F, Boldrini-Franca J, Pinheiro-Junior E, Cardoso I, Zoccal K, et al.
Toxicon
. 2022 Sep;
218:47-56.
PMID: 36063971
In this study we expressed the Ts8, a neurotoxin from Tityus serrulatus scorpion venom, in Pichia pastoris yeast. We evaluated the peptide expression in different conditions, such as pH, temperature,...
10.
Oliveira I, Pucca M, Ferreira I, Cerni F, Jacob B, Wiezel G, et al.
Toxicon
. 2022 Aug;
217:121-130.
PMID: 35998712
Phosphodiesterases (PDEs) constitute an enzyme group able to hydrolyze nucleic acids as well as some second messengers. Due to this ability and their expression in several human tissues and organs,...