Tihomir Tomasic
Overview
Explore the profile of Tihomir Tomasic including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
931
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0
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Recent Articles
1.
Puric E, Hassan M, Sjovall F, Tomasic T, Pevec M, Lah J, et al.
Commun Chem
. 2025 Feb;
8(1):59.
PMID: 39994474
Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar...
2.
Kranjc J, Tomasic T, Pajk S, Brinc M, Pislar A, Anderluh M
ChemMedChem
. 2024 Dec;
e202400896.
PMID: 39714887
Seven different enzymes comprise the galactosyltransferases family, of which β-1,4-galactosyltransferase I (β-1,4-GALT1) is the major contributor to galactosylation activity in cells. Since abnormalities in galactosylation are associated with many pathophysiological...
3.
Piga M, Varga Z, Feher A, Papp F, Korpos E, Bangera K, et al.
J Chem Inf Model
. 2024 Dec;
64(24):9651.
PMID: 39656560
No abstract available.
4.
Poje G, Sakic D, Marinovic M, You J, Tarpley M, Williams K, et al.
Acta Pharm
. 2024 Nov;
74(4):595-612.
PMID: 39560310
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid...
5.
Dernovsek J, Urbancic D, Zajec Z, Sturtzel C, Grissenberger S, Wenninger-Weinzierl A, et al.
Bioorg Chem
. 2024 Oct;
153:107850.
PMID: 39395321
Heat shock protein 90 (Hsp90) and topoisomerase IIα (TopoIIα) are members of the GHKL protein superfamily, both with clinically validated roles as anticancer drug targets. We report the discovery of...
6.
Dernovsek J, Gorican T, Gedgaudas M, Zajec Z, Urbancic D, Jug A, et al.
Eur J Med Chem
. 2024 Oct;
280:116934.
PMID: 39388906
Due to their impact on several oncogenic client proteins, the Hsp90 family of chaperones has been widely studied for the development of potential anticancer agents. Although several Hsp90 inhibitors have...
7.
Cotman A, Fulgheri F, Piga M, Persolja P, Tiz D, Skok Z, et al.
RSC Adv
. 2024 Sep;
14(39):28423-28454.
PMID: 39247510
This study presents the discovery of a new series of -phenylpyrrolamide inhibitors of bacterial DNA gyrase with improved antibacterial activity. The most potent inhibitors had low nanomolar IC values against...
8.
Dernovsek J, Gradisek N, Zajec Z, Urbancic D, Cingl J, Gorican T, et al.
RSC Adv
. 2024 Sep;
14(39):28347-28375.
PMID: 39239280
The interaction between heat shock protein 90 (Hsp90) and Hsp90 co-chaperone cell-division cycle 37 (Cdc37) is crucial for the folding and maturation of several oncogenic proteins, particularly protein kinases. This...
9.
Zidar N, Onali A, Persolja P, Tiz D, Dernovsek J, Skok Z, et al.
Eur J Med Chem
. 2024 Sep;
278:116823.
PMID: 39236496
In this work, we describe an improved series of N-phenylpyrrolamide inhibitors that exhibit potent activity against DNA gyrase and are highly effective against high-priority gram-positive bacteria. The most potent compounds...
10.
Sluga J, Tomasic T, Anderluh M, Hrast Rambaher M, Bajc G, Sevsek A, et al.
Antibiotics (Basel)
. 2024 Aug;
13(8).
PMID: 39200051
Bacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant , which...