Erik R Abels
Overview
Explore the profile of Erik R Abels including associated specialties, affiliations and a list of published articles.
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16
Citations
1677
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Recent Articles
1.
Nieland L, Vrijmoet A, Jetten I, Rufino-Ramos D, de Reus A, Breyne K, et al.
Mol Ther
. 2024 Nov;
33(1):133-151.
PMID: 39563028
Glioblastoma (GB), the most aggressive tumor of the central nervous system (CNS), has poor patient outcomes with limited effective treatments available. MicroRNA-21 (miR-21(a)) is a known oncogene, abundantly expressed in...
2.
Ter Linden E, Abels E, van Solinge T, Neefjes J, Broekman M
Cells
. 2024 Jun;
13(12.
PMID: 38920629
The world of cancer treatment is evolving rapidly and has improved the prospects of many cancer patients. Yet, there are still many cancers where treatment prospects have not (or hardly)...
3.
Nieland L, van Solinge T, Cheah P, Morsett L, El Khoury J, Rissman J, et al.
Mol Ther Oncolytics
. 2022 May;
25:121-136.
PMID: 35572197
Non-coding RNAs, including microRNAs (miRNAs), support the progression of glioma. miR-21 is a small, non-coding transcript involved in regulating gene expression in multiple cellular pathways, including the regulation of proliferation....
4.
Abels E, Nieland L, Hickman S, Broekman M, El Khoury J, Maas S
Int J Mol Sci
. 2021 Feb;
22(3).
PMID: 33540859
One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set of genes termed...
5.
van Solinge T, Abels E, van de Haar L, Hanlon K, Maas S, Schnoor R, et al.
Front Mol Biosci
. 2020 Dec;
7:554649.
PMID: 33282910
Glioma cells exert influence over the tumor-microenvironment in part through the release of extracellular vesicles (EVs), membrane-enclosed structures containing proteins, lipids, and RNAs. In this study, we evaluated the function...
6.
Nieland L, Morsett L, Broekman M, Breakefield X, Abels E
Trends Neurosci
. 2020 Nov;
44(3):215-226.
PMID: 33234347
Glioblastoma the most aggressive form of brain cancer, comprises a complex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and other cell types....
7.
Abels E, Maas S, Tai E, Ting D, Broekman M, Breakefield X, et al.
Sci Rep
. 2020 Jun;
10(1):9898.
PMID: 32555306
Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma progression. Targeting these cells to inhibit their...
8.
Sen P, Wilkie A, Ji F, Yang Y, Taylor I, Velazquez-Palafox M, et al.
Sci Adv
. 2020 Jun;
6(17):eaax9856.
PMID: 32494628
Cytomegalovirus (CMV) is an important cause of morbidity and mortality in the immunocompromised host. In transplant recipients, a variety of clinically important "indirect effects" are attributed to immune modulation by...
9.
Maas S, Abels E, van de Haar L, Zhang X, Morsett L, Sil S, et al.
J Neuroinflammation
. 2020 Apr;
17(1):120.
PMID: 32299465
Background: Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma...
10.
Abels E, Maas S, Nieland L, Wei Z, Cheah P, Tai E, et al.
Cell Rep
. 2019 Sep;
28(12):3105-3119.e7.
PMID: 31533034
Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their microenvironment,...