Erik McShane
Overview
Explore the profile of Erik McShane including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
573
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0
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Recent Articles
1.
Ietswaart R, Smalec B, Xu A, Choquet K, McShane E, Jowhar Z, et al.
Mol Cell
. 2024 Jul;
84(14):2765-2784.e16.
PMID: 38964322
Dissecting the regulatory mechanisms controlling mammalian transcripts from production to degradation requires quantitative measurements of mRNA flow across the cell. We developed subcellular TimeLapse-seq to measure the rates at which...
2.
McShane E, Churchman L
Hum Mol Genet
. 2024 May;
33(R1):R34-R41.
PMID: 38779776
In human cells, the nuclear and mitochondrial genomes engage in a complex interplay to produce dual-encoded oxidative phosphorylation (OXPHOS) complexes. The coordination of these dynamic gene expression processes is essential...
3.
McShane E, Couvillion M, Ietswaart R, Prakash G, Smalec B, Soto I, et al.
Mol Cell
. 2024 Mar;
84(8):1541-1555.e11.
PMID: 38503286
Oxidative phosphorylation (OXPHOS) complexes, encoded by both mitochondrial and nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial gene expression steps are coordinated to achieve balanced...
4.
McShane E, Couvillion M, Ietswaart R, Prakash G, Smalec B, Soto I, et al.
bioRxiv
. 2023 Feb;
PMID: 36824735
Oxidative phosphorylation (OXPHOS) complexes, encoded by both mitochondrial and nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial gene expression steps are coordinated to achieve balanced...
5.
Soto I, Couvillion M, Hansen K, McShane E, Moran J, Barrientos A, et al.
Genome Biol
. 2022 Aug;
23(1):170.
PMID: 35945592
Background: Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To determine how human cells...
6.
McShane E, Selbach M
Annu Rev Cell Dev Biol
. 2022 May;
38:241-262.
PMID: 35587265
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal,...
7.
Taggart J, Zauber H, Selbach M, Li G, McShane E
Cell Syst
. 2020 Feb;
10(2):125-132.
PMID: 32105631
How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing...
8.
von Hoff L, Kargel E, Franke V, McShane E, Schulz-Beiss K, Patone G, et al.
Blood
. 2019 Jan;
133(13):1489-1494.
PMID: 30696620
Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this...
9.
Isaac R, McShane E, Churchman L
Annu Rev Genet
. 2018 Sep;
52:511-533.
PMID: 30230928
Together, the nuclear and mitochondrial genomes encode the oxidative phosphorylation (OXPHOS) complexes that reside in the mitochondrial inner membrane and enable aerobic life. Mitochondria maintain their own genome that is...
10.
Kim M, Wende H, Walcher J, Kuhnemund J, Cheret C, Kempa S, et al.
Genes Dev
. 2018 Aug;
32(15-16):1101.
PMID: 30068704
No abstract available.