Erik de Leeuw
Overview
Explore the profile of Erik de Leeuw including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
798
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Recent Articles
1.
Malin J, de Leeuw E
Infect Drug Resist
. 2019 Nov;
12:2613-2625.
PMID: 31692545
Resistance against commonly used antibiotics has emerged in all bacterial pathogens. In fact, there is no antibiotic currently in clinical use against which resistance has not been reported. In particular,...
2.
Howell K, de Leeuw E
Biochem Biophys Res Commun
. 2018 May;
502(2):238-242.
PMID: 29800568
Effector peptides of innate immunity play an important role in host defense. They act directly by inactivating microbes but also link innate to adaptive immunity. A variety of innate immune...
3.
Zou G, de Leeuw E
Biochem Biophys Res Commun
. 2018 May;
501(2):454-457.
PMID: 29738776
Pseudomonas aeruginosa produces a large number of virulence factors, including the extracellular protein, Exotoxin A (ETA). Human Neutrophil Peptide 1 (HNP1) neutralizes the Exotoxin A. HNP1 belongs to the family...
4.
Zhao A, Lu W, de Leeuw E
Biochem Biophys Res Commun
. 2015 Oct;
467(4):967-72.
PMID: 26474700
The gut epithelium is critically involved in maintaining intestinal immune homeostasis. Acting as a physical barrier, it separates the intestinal microflora from cells of the immune system. In addition to...
5.
Lu W, de Leeuw E
FEBS Lett
. 2014 Apr;
588(10):1906-12.
PMID: 24681099
Defensins are cationic antimicrobial peptides that contribute to regulation of host cell function also. Here, we report on the regulation of cell death by Human Defensin 5, the major antimicrobial...
6.
Lu W, de Leeuw E
Biochem Biophys Res Commun
. 2013 Jun;
436(3):557-62.
PMID: 23770364
Defensins are cationic antimicrobial peptides that play an important role in innate immunity by primarily acting against microbes. Their antimicrobial properties have been widely studied and are well understood. Defensins...
7.
Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, et al.
J Biol Chem
. 2012 May;
287(26):21615-27.
PMID: 22573326
Human α-defensins are cationic peptides that self-associate into dimers and higher-order oligomers. They bind protein toxins, such as anthrax lethal factor (LF), and kill bacteria, including Escherichia coli and Staphylococcus...
8.
Pazgier M, Wei G, Ericksen B, Jung G, Wu Z, de Leeuw E, et al.
J Biol Chem
. 2012 Jan;
287(12):8944-53.
PMID: 22270360
Human myeloid α-defensins called HNPs play multiple roles in innate host defense. The Trp-26 residue of HNP1 was previously shown to contribute importantly to its ability to kill S. aureus,...
9.
Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, et al.
J Biol Chem
. 2010 Mar;
285(21):16275-85.
PMID: 20220136
We performed a comprehensive alanine scan of human alpha-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal factor, and bind human immunodeficiency...
10.
de Leeuw E, Li C, Zeng P, Li C, Diepeveen-de Buin M, Lu W, et al.
FEBS Lett
. 2010 Mar;
584(8):1543-8.
PMID: 20214904
Defensins constitute a major class of cationic antimicrobial peptides in mammals and vertebrates, acting as effectors of innate immunity against infectious microorganisms. It is generally accepted that defensins are bactericidal...