Erik de Leeuw
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Explore the profile of Erik de Leeuw including associated specialties, affiliations and a list of published articles.
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26
Citations
798
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Recent Articles
11.
Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, et al.
J Biol Chem
. 2009 Jul;
284(42):29180-92.
PMID: 19640840
Despite the small size and conserved tertiary structure of defensins, little is known at a molecular level about the basis of their functional versatility. For insight into the mechanism(s) of...
12.
de Leeuw E, Rajabi M, Zou G, Pazgier M, Lu W
FEBS Lett
. 2009 Jul;
583(15):2507-12.
PMID: 19589339
Defensins constitute a major family of natural antimicrobial peptides that protect the host against microbial invasion. Here, we report on the antibacterial properties and cellular interaction of Human Defensin 5...
13.
Zou G, de Leeuw E, Lubkowski J, Lu W
J Mol Biol
. 2008 Jul;
381(5):1281-91.
PMID: 18616948
Human neutrophil alpha-defensins (HNPs) are cationic antimicrobial peptides that are synthesized in vivo as inactive precursors (proHNPs). Activation requires proteolytic excision of their anionic N-terminal inhibitory pro peptide. The pro...
14.
Rajabi M, de Leeuw E, Pazgier M, Li J, Lubkowski J, Lu W
J Biol Chem
. 2008 May;
283(31):21509-18.
PMID: 18499668
Mammalian alpha-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable disulfide bonds and...
15.
Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, et al.
J Biol Chem
. 2007 Apr;
282(27):19653-65.
PMID: 17452329
Human defensins are a family of small antimicrobial proteins found predominantly in leukocytes and epithelial cells that play important roles in the innate and adaptive immune defense against microbial infection....
16.
Wu Z, Li X, Ericksen B, de Leeuw E, Zou G, Zeng P, et al.
J Mol Biol
. 2007 Mar;
368(2):537-49.
PMID: 17355880
Human neutrophil alpha-defensins (HNPs) are synthesized in vivo as inactive precursor proteins, i.e. preproHNPs. A series of sequential proteolytic events excise the N-terminal inhibitory pro peptide, leading to defensin maturation...
17.
de Leeuw E, Lu W
Infect Disord Drug Targets
. 2007 Mar;
7(1):67-70.
PMID: 17346213
Defensins are a family of antimicrobial cationic peptides that act as a rapid response force against microbial invasion in a wide range of organisms, including plants, insects, animals and humans....
18.
de Leeuw E, Burks S, Li X, Kao J, Lu W
FEBS Lett
. 2007 Jan;
581(3):515-20.
PMID: 17250830
The mucosal epithelium secretes a variety of antimicrobial peptides that act as part of the innate immune system to protect against invading microbes. Here, we describe the functional properties of...
19.
de Leeuw E, Li X, Lu W
FEMS Microbiol Lett
. 2006 Jul;
260(2):210-5.
PMID: 16842346
Self-assembling proteins that form crystalline surface layers on many microorganisms can be involved in bacterial-host adhesion via specific interactions with components of the extracellular matrix. Here, we describe the interaction...
20.
Li X, de Leeuw E, Lu W
Biochemistry
. 2005 Nov;
44(44):14688-94.
PMID: 16262268
Human psoriasin (S100A7), a member of the S100 family of calcium-binding proteins, is richly expressed in keratinocytes of patients suffering from psoriasis. To date, the exact physiological function of psoriasin...