Erick Kindt
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Explore the profile of Erick Kindt including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
252
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0
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Recent Articles
1.
Esquejo R, Albuquerque B, Sher A, Blatnik M, Wald K, Peloquin M, et al.
Heliyon
. 2022 Oct;
8(10):e11091.
PMID: 36303906
The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in skeletal muscle metabolism. Therapeutics that selectively activate...
2.
Li W, Zhang C, Huser N, Ray C, Fountain S, Kindt E
Bioanalysis
. 2021 Mar;
13(6):481-491.
PMID: 33724050
Develop a quantitative LC-MS/MS method for FDG, FDG-monophosphate, glucose and glucose-monophosphate in mouse tumor models to assist in validating the use of [F]FDG-positron emission tomography (PET) imaging for anticancer therapies...
3.
Guerrero Y, Desai D, Sullivan C, Kindt E, Spilker M, Maurer T, et al.
AAPS J
. 2020 Mar;
22(2):53.
PMID: 32124093
Static in vitro cell culture studies cannot capture the dynamic concentration profiles of drugs, nutrients, and other factors that cells experience in physiological systems. This limits the confidence in the...
4.
Bartlett D, Wu A, Li X, Kraus M, Wang H, Kindt E
J Pharm Sci
. 2019 May;
108(9):3124-3129.
PMID: 31136767
Microdialysis is a technique that utilizes a semipermeable membrane to sample analytes present within tissue interstitial fluid. Analyte-specific calibration is required for quantitative microdialysis, but these calibration methods are tedious,...
5.
Cokorinos E, Delmore J, Reyes A, Albuquerque B, Kjobsted R, Jorgensen N, et al.
Cell Metab
. 2017 May;
25(5):1147-1159.e10.
PMID: 28467931
The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators...
6.
Kalabat D, Vitsky A, Scott W, Kindt E, Hayes K, John-Baptiste A, et al.
Toxicol Pathol
. 2016 May;
45(2):302-320.
PMID: 27189632
Gastrointestinal toxicity is dose limiting with many therapeutic and anticancer agents. Real-time, noninvasive detection of markers of toxicity in biofluids is advantageous. Ongoing research has revealed microRNAs as potential diagnostic...
7.
Faria M, Halquist M, Kindt E, Li W, Karnes H, OBrien P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Sep;
907:13-20.
PMID: 22995377
Thymidine kinase 1 (TK1) is an enzyme involved in DNA synthesis whose activity in serum is indicative of tumor proliferation and the severity of blood malignancies. 3'-deoxy-3'-fluorothymidine (FLT), a specific...
8.
John-Baptiste A, Huang W, Kindt E, Wu A, Vitsky A, Scott W, et al.
Toxicol Pathol
. 2012 Mar;
40(3):482-90.
PMID: 22395791
Although gastrointestinal (GI) toxicity is a significant dose-limiting safety concern noted in multiple therapeutic areas, there are no GI biomarkers that can accurately track, precede, or reliably correlate with histologic...
9.
Pfefferkorn J, Litchfield J, Hutchings R, Cheng X, Larsen S, Auerbach B, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(9):2725-31.
PMID: 21183342
The design of drugs with selective tissue distribution can be an effective strategy for enhancing efficacy and safety, but understanding the translation of preclinical tissue distribution data to the clinic...
10.
Kindt E, Szekely-Klepser G, Fountain S
Biomed Chromatogr
. 2010 Nov;
25(3):323-9.
PMID: 21110384
A simple plasma extraction method coupled with liquid chromatography-tandem mass spectrometry (LC/MS/MS) detection was developed and validated for the analysis of endogenous mevalonic acid (MVA), a biomarker indicative of the...