Jake Delmore
Overview
Explore the profile of Jake Delmore including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
18
Citations
701
Followers
0
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Related Specialties
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Recent Articles
1.
McMillin D, Delmore J, Weisberg E, Negri J, Geer C, Klippel S, et al.
Nat Med
. 2024 Feb;
30(4):1214.
PMID: 38355975
No abstract available.
2.
Flach R, Bollinger E, Reyes A, Laforest B, Kormos B, Liu S, et al.
Nat Commun
. 2023 Aug;
14(1):4812.
PMID: 37558654
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which...
3.
Esquejo R, Albuquerque B, Sher A, Blatnik M, Wald K, Peloquin M, et al.
Heliyon
. 2022 Oct;
8(10):e11091.
PMID: 36303906
The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in skeletal muscle metabolism. Therapeutics that selectively activate...
4.
Ryder T, Calabrese M, Walker G, Cameron K, Reyes A, Borzilleri K, et al.
J Med Chem
. 2018 Jul;
61(16):7273-7288.
PMID: 30036059
Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have culminated in the identification of PF-06409577 (1), PF-06885249 (2), and PF-06679142 (3)...
5.
Esquejo R, Salatto C, Delmore J, Albuquerque B, Reyes A, Shi Y, et al.
EBioMedicine
. 2018 Apr;
31:122-132.
PMID: 29673898
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated...
6.
Cokorinos E, Delmore J, Reyes A, Albuquerque B, Kjobsted R, Jorgensen N, et al.
Cell Metab
. 2017 May;
25(5):1147-1159.e10.
PMID: 28467931
The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators...
7.
OConnor R, Ooi M, Meiller J, Jakubikova J, Klippel S, Delmore J, et al.
Cancer Chemother Pharmacol
. 2013 Apr;
71(5):1357-68.
PMID: 23589314
Purpose: Bortezomib is an important agent in multiple myeloma treatment, but resistance in cell lines and patients has been described. The main mechanisms of resistance described in cancer fall into...
8.
Klippel S, Jakubikova J, Delmore J, Ooi M, McMillin D, Kastritis E, et al.
Br J Haematol
. 2012 Sep;
159(3):340-51.
PMID: 22970818
Jasmonates, plant stress hormones, have been demonstrated to be effective in killing various types of cancer cells. We therefore tested if methyljasmonate (MJ) has activity against multiple myeloma (MM) in...
9.
Cao S, McMillin D, Tamayo G, Delmore J, Mitsiades C, Clardy J
J Nat Prod
. 2012 Mar;
75(4):793-7.
PMID: 22458669
CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context...
10.
McMillin D, Delmore J, Negri J, Vanneman M, Koyama S, Schlossman R, et al.
Blood
. 2012 Feb;
119(15):e131-8.
PMID: 22289890
Conventional assays evaluating antitumor activity of immune effector cells have limitations that preclude their high-throughput application. We adapted the recently developed Compartment-Specific Bioluminescence Imaging (CS-BLI) technique to perform high-throughput quantification...