Eric S Lightcap
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Explore the profile of Eric S Lightcap including associated specialties, affiliations and a list of published articles.
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14
Citations
680
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Recent Articles
1.
Stokes M, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, et al.
Clin Cancer Res
. 2023 Sep;
29(23):4870-4882.
PMID: 37733811
Purpose: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation strategy. Here, we tested the hypothesis...
2.
Lightcap E, Yu P, Grossman S, Song K, Khattar M, Xega K, et al.
Sci Transl Med
. 2021 Sep;
13(611):eaba7791.
PMID: 34524860
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small-molecule inhibitor of SUMOylation,...
3.
He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, et al.
Nat Chem Biol
. 2017 Sep;
13(11):1164-1171.
PMID: 28892090
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a...
4.
Xiao A, Lightcap E, Bouck D
J Biomol Screen
. 2015 May;
20(8):957-64.
PMID: 25924619
Gene knockdown by small interfering RNA (siRNA) has been used extensively to investigate the function of genes in targeted and genome-wide studies. One of the primary challenges of siRNA studies...
5.
Garcia K, Blank J, Bouck D, Liu X, Sappal D, Hather G, et al.
Mol Cancer Ther
. 2014 Mar;
13(6):1625-35.
PMID: 24672057
MLN4924 is an investigational small-molecule inhibitor of the Nedd8-activating enzyme currently in phase I clinical trials. MLN4924 induces DNA damage via rereplication in most cell lines. This distinct mechanism of...
6.
Blank J, Liu X, Cosmopoulos K, Bouck D, Garcia K, Bernard H, et al.
Cancer Res
. 2012 Oct;
73(1):225-34.
PMID: 23100467
MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE) in phase I clinical trials. NAE inhibition prevents the ubiquitination and proteasomal degradation of substrates for cullin-RING ubiquitin E3...
7.
Worster D, Schmelzle T, Solimini N, Lightcap E, Millard B, Mills G, et al.
Sci Signal
. 2012 Mar;
5(214):ra19.
PMID: 22394561
Epithelial cells respond to growth factors including epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), and insulin. Using high-content immunofluorescence microscopy, we quantitated differences in signaling networks downstream of...
8.
Liao H, Liu X, Blank J, Bouck D, Bernard H, Garcia K, et al.
Mol Cell Proteomics
. 2011 Aug;
10(11):M111.009183.
PMID: 21873567
Cullin-RING ubiquitin ligases (CRLs) are responsible for the ubiquitination of many cellular proteins, thereby targeting them for proteasomal degradation. In most cases the substrates of the CRLs have not been...
9.
Chen S, Blank J, Peters T, Liu X, Rappoli D, Pickard M, et al.
Cancer Res
. 2010 May;
70(11):4318-26.
PMID: 20460535
Multiple pathways have been proposed to explain how proteasome inhibition induces cell death, but mechanisms remain unclear. To approach this issue, we performed a genome-wide siRNA screen to evaluate the...
10.
Wolfer A, Wittner B, Irimia D, Flavin R, Lupien M, Gunawardane R, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(8):3698-703.
PMID: 20133671
Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding,...