Eric Rynes
Overview
Explore the profile of Eric Rynes including associated specialties, affiliations and a list of published articles.
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17
Citations
6371
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Recent Articles
1.
Hitz B, Lee J, Jolanki O, Kagda M, Graham K, Sud P, et al.
Res Sq
. 2023 Jul;
PMID: 37503119
The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000...
2.
Hitz B, Jin-Wook L, Jolanki O, Kagda M, Graham K, Sud P, et al.
bioRxiv
. 2023 Apr;
PMID: 37066421
The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000...
3.
Brandstetter K, Zulske T, Ragoczy T, Horl D, Guirao-Ortiz M, Steinek C, et al.
Biophys J
. 2022 Feb;
121(6):977-990.
PMID: 35150617
Methodological advances in conformation capture techniques have fundamentally changed our understanding of chromatin architecture. However, the nanoscale organization of chromatin and its cell-to-cell variance are less studied. Analyzing genome-wide data...
4.
Vierstra J, Lazar J, Sandstrom R, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
583(7818):729-736.
PMID: 32728250
Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits, but it...
5.
Meuleman W, Muratov A, Rynes E, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
584(7820):244-251.
PMID: 32728217
DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA and contain genetic variations associated with diseases and phenotypic traits. We created high-resolution maps of DHSs from 733 human...
6.
Siebenthall K, Miller C, Vierstra J, Mathieu J, Tretiakova M, Reynolds A, et al.
EBioMedicine
. 2019 Mar;
41:427-442.
PMID: 30827930
Background: Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible...
7.
Polak P, Karlic R, Koren A, Thurman R, Sandstrom R, Lawrence M, et al.
Nature
. 2015 Feb;
518(7539):360-364.
PMID: 25693567
Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the human genome. Instead, different human genomic regions vary by up to fivefold...
8.
Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen R, et al.
Science
. 2014 Nov;
346(6212):1007-12.
PMID: 25411453
To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, and systematically compared these with human DHS...
9.
Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, et al.
Nature
. 2014 Nov;
515(7527):355-64.
PMID: 25409824
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To...
10.
Chan M, Wooden J, Tsang M, Gilligan D, Hirenallur-S D, Finney G, et al.
PLoS One
. 2013 Feb;
8(2):e54902.
PMID: 23424621
Hematopoietic protein-1 (Hem-1) is a hematopoietic cell specific member of the WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex, which regulates filamentous actin (F-actin) polymerization in many cell types including immune cells....