Eric Lazartigues
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Explore the profile of Eric Lazartigues including associated specialties, affiliations and a list of published articles.
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3847
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Recent Articles
1.
Chhabra K, Shoemaker R, Herath C, Thomas M, Filipeanu C, Lazartigues E
Physiol Rev
. 2025 Feb;
PMID: 39918873
Angiotensin Converting Enzyme 2 (ACE2) was discovered 25 years ago as a negative regulator of renin-angiotensin system, opposing the effects of angiotensin-II. Beyond its well-demonstrated roles in cardiovascular regulation and...
2.
Elgazzaz M, Lakkappa N, Berdasco C, Mohan U, Nuzzo A, Restivo L, et al.
Hypertension
. 2024 Nov;
82(1):84-95.
PMID: 39601126
Background: Ang-II (angiotensin II) impairs the function of the antihypertensive enzyme ACE2 (angiotensin-converting enzyme 2) by promoting its internalization, ubiquitination, and degradation, thus contributing to hypertension. However, few ACE2 ubiquitination...
3.
Whitehead A, Wang Z, Boustany R, Vives R, Lazartigues E, Liu J, et al.
Matrix Biol
. 2024 Oct;
134:107-118.
PMID: 39368561
The heparan sulfate (HS) 6-O-endosulfatases or the Sulfs (Sulf1 and Sulf2) are the only known enzymes that can modify HS sulfation status extracellularly and have been shown to regulate diverse...
4.
Tiwari P, Elgazzaz M, Lazartigues E, Hanif K
Int Immunopharmacol
. 2024 Jul;
139:112654.
PMID: 38996777
Hypertension causes platelet activation and adhesion in the brain resulting in glial activation and neuroinflammation. Further, activation of Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor (ACE2/Ang (1-7)/MasR) axis of central Renin-Angiotensin System...
5.
Doiron J, Xia H, Yu X, Nevins A, LaPenna K, Sharp 3rd T, et al.
Br J Pharmacol
. 2024 Jul;
181(21):4294-4310.
PMID: 38982742
Background And Purpose: Sodium glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a potent therapy for heart failure with preserved ejection fraction (HFpEF). Hydrogen sulphide (HS), a well-studied cardioprotective agent,...
6.
Currey J, Ellsworth C, Shamima Khatun M, Wang C, Chen Z, Liu S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jun;
1870(7):167322.
PMID: 38942338
Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which 2-3-month-old K18-hACE2 (K18) mice...
7.
Elgazzaz M, Lakkappa N, Berdasco C, Mohan U, Nuzzo A, Restivo L, et al.
medRxiv
. 2024 Jun;
PMID: 38826318
Background: Angiotensin (Ang)-II impairs the function of the antihypertensive enzyme ACE2 by promoting its internalization, ubiquitination and degradation thus contributing to hypertension. However, few ACE2 ubiquitination partners have been identified...
8.
Elgazzaz M, Filipeanu C, Lazartigues E
Hypertension
. 2024 Apr;
81(7):1438-1449.
PMID: 38567498
ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well recognized as an important member of the (RAS) renin-angiotensin system with important roles in the regulation of cardiovascular function by...
9.
Elgazzaz M, Berdasco C, Garai J, Baddoo M, Lu S, Daoud H, et al.
Mol Metab
. 2023 Dec;
80:101864.
PMID: 38159883
Objective: Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this...
10.
Whitehead A, Li Z, LaPenna K, Abbes N, Sharp T, Lefer D, et al.
Am J Physiol Heart Circ Physiol
. 2023 Dec;
326(1):H278-H290.
PMID: 38038717
Smoking and high-fat diet (HFD) consumption are two modifiable risk factors for cardiovascular (CV) diseases, and individuals who are overweight or obese due to unhealthy diet are more likely to...