Srinivas Sriramula
Overview
Explore the profile of Srinivas Sriramula including associated specialties, affiliations and a list of published articles.
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45
Citations
2295
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Recent Articles
1.
Theobald D, de Castro Braz L, Akula S, Eells J, Sriramula S
Am J Physiol Heart Circ Physiol
. 2025 Feb;
328(3):H711-H718.
PMID: 39982452
Long COVID has been associated with significant cardiovascular complications, including fibrosis, functional impairment, and chronic inflammatory and immune responses. However, the underlying mechanisms driving these cardiac pathologies following COVID-19 infection...
2.
Elgazzaz M, Lakkappa N, Berdasco C, Mohan U, Nuzzo A, Restivo L, et al.
Hypertension
. 2024 Nov;
82(1):84-95.
PMID: 39601126
Background: Ang-II (angiotensin II) impairs the function of the antihypertensive enzyme ACE2 (angiotensin-converting enzyme 2) by promoting its internalization, ubiquitination, and degradation, thus contributing to hypertension. However, few ACE2 ubiquitination...
3.
Williams M, Morgan J, Bullock M, Poovey C, Wisniewski M, Francisco J, et al.
Am J Physiol Heart Circ Physiol
. 2024 Sep;
327(5):H1210-H1229.
PMID: 39269448
Phenotypic transformation of vascular smooth muscle (VSM) from a contractile state to a synthetic, proliferative state is a hallmark of cardiovascular disease (CVD). In CVD, diseased tissue often becomes acidic...
4.
Elgazzaz M, Lakkappa N, Berdasco C, Mohan U, Nuzzo A, Restivo L, et al.
medRxiv
. 2024 Jun;
PMID: 38826318
Background: Angiotensin (Ang)-II impairs the function of the antihypertensive enzyme ACE2 by promoting its internalization, ubiquitination and degradation thus contributing to hypertension. However, few ACE2 ubiquitination partners have been identified...
5.
Sriramula S, Theobald D, Parekh R, Akula S, ORourke D, Eells J
Cells
. 2023 Aug;
12(16).
PMID: 37626917
Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible...
6.
Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, et al.
Cardiovasc Res
. 2023 May;
119(11):2130-2141.
PMID: 37161607
Aims: Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory renin-angiotensin system that is down-regulated during the development of hypertension, possibly via ubiquitination. However, little is known about...
7.
Theobald D, Nair A, Sriramula S, Francis J
Front Cardiovasc Med
. 2023 Apr;
10:1074700.
PMID: 37034342
Toll-like receptor 4 (TLR4) is an integral factor in the initiation of the innate immune response and plays an important role in cardiovascular diseases such as hypertension and myocardial infarction....
8.
Theobald D, Sriramula S
Antioxidants (Basel)
. 2023 Jan;
12(1).
PMID: 36671012
Hypertension is associated with increased expression of kinin B1 receptors (B1R) and increased levels of pro-inflammatory cytokines within the neurons. We previously reported that angiotensin II (Ang II) upregulates B1R...
9.
Byrne S, Vishwakarma N, Sriramula S, Katwa L
Life Sci
. 2022 Aug;
308:120918.
PMID: 36041503
Dopamine receptors have been extensively studied in the mammalian brain and spinal cord, as dopamine is a vital determinant of bodily movement, cognition, and overall behavior. Thus, dopamine receptor antagonist...
10.
Smeyne R, Eells J, Chatterjee D, Byrne M, Akula S, Sriramula S, et al.
Mov Disord
. 2022 May;
37(7):1394-1404.
PMID: 35579496
Background: Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities...