Eric I Rossman
Overview
Explore the profile of Eric I Rossman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
234
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Pugsley M, Guth B, Chiang A, Doyle J, Engwall M, Guillon J, et al.
J Pharmacol Toxicol Methods
. 2017 Jan;
85:1-21.
PMID: 28065821
Introduction: The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety...
12.
Payseur J, Rigney J, Turner S, Wu X, Murphy D, Rossman E
J Pharmacol Toxicol Methods
. 2016 Apr;
81:115-9.
PMID: 27050559
Introduction: Currently, standard methods for measuring cardiac output are either invasive (i.e. flow probe) or are limited in terms of short measurement intervals and measurement variability (i.e. echocardiography). The ability...
13.
Guth B, Chiang A, Doyle J, Engwall M, Guillon J, Hoffmann P, et al.
J Pharmacol Toxicol Methods
. 2015 Apr;
75:70-90.
PMID: 25843226
Introduction: Drug-induced effects on the cardiovascular system remain a major cause of drug attrition. While hemodynamic (blood pressure (BP) and heart rate (HR)) and electrophysiological methods have been used in...
14.
Laurent G, Leong-Poi H, Mangat I, Moe G, Hu X, So P, et al.
Circ Arrhythm Electrophysiol
. 2009 Oct;
2(2):171-8.
PMID: 19808462
Background: Abnormal intercellular communication caused by connexin dysfunction may contribute to atrial fibrillation (AF). The present study assessed the effect of the gap junction conduction-enhancing antiarrhythmic peptide GAP-134 on AF...
15.
Hennan J, Swillo R, Morgan G, Rossman E, Kantrowitz J, Butera J, et al.
J Cardiovasc Pharmacol Ther
. 2009 Sep;
14(3):207-14.
PMID: 19721133
The antiarrhythmic dipeptide, GAP-134, ([2S,4R]-1[2-aminoacetyl]-4-benzamido-pyrrolidine-2-carboxylic acid) was evaluated in canine ischemia/reperfusion model. In dogs subjected to 60-minute ischemia and 4-hour reperfusion, GAP-134 was administered 10 minutes before reperfusion as a...
16.
Chekler E, Butera J, Di L, Swillo R, Morgan G, Rossman E, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(16):4551-4.
PMID: 19616941
In an effort to discover potent, orally bioavailable compounds for the treatment of atrial fibrillation (AF) and ventricular tachycardia (VT), we developed a class of gap-junction modifiers typified by GAP-134...
17.
Rossman E, Liu K, Morgan G, Swillo R, Krueger J, Gardell S, et al.
J Pharmacol Exp Ther
. 2009 Mar;
329(3):1127-33.
PMID: 19252062
Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Our objective was to...
18.
Butera J, Larsen B, Hennan J, Kerns E, Di L, Alimardanov A, et al.
J Med Chem
. 2009 Jan;
52(4):908-11.
PMID: 19175320
Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. Small molecule gap-junction modifiers with improved physical properties were identified from a Zealand Pharma peptide library...
19.
Quaile M, Rossman E, Berretta R, Bratinov G, Kubo H, Houser S, et al.
J Mol Cell Cardiol
. 2007 Oct;
43(5):552-63.
PMID: 17931654
Myocardial contractile reserve is significantly attenuated in patients with advanced heart failure. The aim of this study was to identify mechanisms of impaired contractile reserve in a large animal model...
20.
Petre R, Quaile M, Rossman E, Ratcliffe S, Bailey B, Houser S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2006 Sep;
292(2):R810-8.
PMID: 17008460
Recent studies have identified sex differences in heart function that may affect the risk of developing heart failure. We hypothesized that there are fundamental differences in calcium (Ca) regulation in...