Robert E Swillo
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Explore the profile of Robert E Swillo including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
136
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Recent Articles
1.
Hennan J, Swillo R, Morgan G, Rossman E, Kantrowitz J, Butera J, et al.
J Cardiovasc Pharmacol Ther
. 2009 Sep;
14(3):207-14.
PMID: 19721133
The antiarrhythmic dipeptide, GAP-134, ([2S,4R]-1[2-aminoacetyl]-4-benzamido-pyrrolidine-2-carboxylic acid) was evaluated in canine ischemia/reperfusion model. In dogs subjected to 60-minute ischemia and 4-hour reperfusion, GAP-134 was administered 10 minutes before reperfusion as a...
2.
Chekler E, Butera J, Di L, Swillo R, Morgan G, Rossman E, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(16):4551-4.
PMID: 19616941
In an effort to discover potent, orally bioavailable compounds for the treatment of atrial fibrillation (AF) and ventricular tachycardia (VT), we developed a class of gap-junction modifiers typified by GAP-134...
3.
Rossman E, Liu K, Morgan G, Swillo R, Krueger J, Gardell S, et al.
J Pharmacol Exp Ther
. 2009 Mar;
329(3):1127-33.
PMID: 19252062
Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Our objective was to...
4.
Butera J, Larsen B, Hennan J, Kerns E, Di L, Alimardanov A, et al.
J Med Chem
. 2009 Jan;
52(4):908-11.
PMID: 19175320
Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. Small molecule gap-junction modifiers with improved physical properties were identified from a Zealand Pharma peptide library...
5.
Hennan J, Swillo R, Morgan G, Leik C, Brooks J, Shaw G, et al.
Thromb Haemost
. 2006 Mar;
95(3):469-75.
PMID: 16525575
Under high shear arterial blood flow von Willebrand Factor (vWF) binds the platelet receptor glycoprotein (GP) Ibalpha, leading to platelet adhesion, activation and thrombosis. Blockade of vWF-GPIb alpha interactions by...
6.
Hennan J, Swillo R, Morgan G, Keith Jr J, Schaub R, Smith R, et al.
J Pharmacol Exp Ther
. 2005 Dec;
317(1):236-43.
PMID: 16344331
The antiarrhythmic and cardioprotective effect of increasing gap junction intercellular communication during ischemia/reperfusion injury has not been studied. The antiarrhythmic peptide rotigaptide (previously ZP123), which maintains gap junction intercellular communication,...
7.
Hennan J, Elokdah H, Leal M, Ji A, Friedrichs G, Morgan G, et al.
J Pharmacol Exp Ther
. 2005 Apr;
314(2):710-6.
PMID: 15860572
We tested a novel, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) in a canine model of electrolytic injury. Dogs received by oral gavage either vehicle (control) or the PAI-1...
8.
Crandall D, Hennan J, Elokdah H, Krishnamurthy G, Antrilli T, Bauer J, et al.
Biochem Biophys Res Commun
. 2003 Nov;
311(4):904-8.
PMID: 14623266
Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of tissue plasminogen activator (tPA) and is elevated in diseases of vascular remodeling. In this study, we describe an inhibitor of...
9.
Friedrichs G, Swillo R, Jow B, Bridal T, Numann R, Warner L, et al.
J Cardiovasc Pharmacol
. 2001 Dec;
39(1):18-28.
PMID: 11743224
Contractility studies in isolated feline myocytes have demonstrated that sphingosine, a metabolite stimulated by tumor necrosis factor (TNF) binding, decreases intracellular calcium release and depresses inotropic activity. This study investigated...