Jose M Sanchez-Ruiz
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Explore the profile of Jose M Sanchez-Ruiz including associated specialties, affiliations and a list of published articles.
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Articles
93
Citations
1971
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Recent Articles
1.
Demkiv A, Toledo-Patino S, Medina-Carmona E, Berg A, Pinto G, Parracino A, et al.
Mol Biol Evol
. 2025 Mar;
PMID: 40070202
At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution proposes that this 6-8 residue motif could have sparked the...
2.
Keser M, Mateljak I, Kittl R, Ludwig R, Risso V, Sanchez-Ruiz J, et al.
ACS Synth Biol
. 2024 Dec;
14(1):239-246.
PMID: 39670334
Galactose oxidase (GOase) is a versatile biocatalyst with a wide range of potential applications, ranging from synthetic chemistry to bioelectrochemical devices. Previous GOase engineering by directed evolution generated the M-RQW...
3.
Gutierrez-Rus L, Gamiz-Arco G, Gavira J, Gaucher E, Risso V, Sanchez-Ruiz J
Mol Biol Evol
. 2023 May;
40(6).
PMID: 37235753
Enzymes catalyze the chemical reactions of life. For nearly half of known enzymes, catalysis requires the binding of small molecules known as cofactors. Polypeptide-cofactor complexes likely formed at a primordial...
4.
Gutierrez-Rus L, Gamiz-Arco G, Gavira J, Gaucher E, Risso V, Sanchez-Ruiz J
bioRxiv
. 2023 Mar;
PMID: 36993774
Enzymes catalyze the chemical reactions of life. For nearly half of known enzymes, catalysis requires the binding of small molecules known as cofactors. Polypeptide-cofactor complexes likely formed at a primordial...
5.
Severino R, Moreno-Paz M, Puente-Sanchez F, Sanchez-Garcia L, Risso V, Sanchez-Ruiz J, et al.
Anal Chem
. 2023 Mar;
95(12):5323-5330.
PMID: 36926836
Several mass spectrometry and spectroscopic techniques have been used in the search for molecular biomarkers on Mars. A major constraint is their capability to detect and identify large and complex...
6.
Medina-Carmona E, Gutierrez-Rus L, Manssour-Triedo F, Newton M, Gamiz-Arco G, Mota A, et al.
Mol Biol Evol
. 2023 Feb;
40(3).
PMID: 36788592
Many metabolites are generated in one step of a biochemical pathway and consumed in a subsequent step. Such metabolic intermediates are often reactive molecules which, if allowed to freely diffuse...
7.
Gutierrez-Rus L, Alcalde M, Risso V, Sanchez-Ruiz J
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012203
The routine generation of enzymes with completely new active sites is a major unsolved problem in protein engineering. Advances in this field have thus far been modest, perhaps due, at...
8.
Sanchez-Ruiz J, Ibarra-Molero B
Methods Mol Biol
. 2021 Nov;
2376:105-116.
PMID: 34845605
Protein folding/unfolding processes involve a large number of weak, non-covalent interactions and are more appropriately described in terms of the movement of a point representing protein conformation in a plot...
9.
Gamiz-Arco G, Risso V, Gaucher E, Gavira J, Naganathan A, Ibarra-Molero B, et al.
J Mol Biol
. 2021 Oct;
433(24):167321.
PMID: 34687715
Obligate symbionts typically exhibit high evolutionary rates. Consequently, their proteins may differ considerably from their modern and ancestral homologs in terms of both sequence and properties, thus providing excellent models...
10.
Luzon-Hidalgo R, Risso V, Delgado A, Ibarra-Molero B, Sanchez-Ruiz J
STAR Protoc
. 2021 Sep;
2(3):100784.
PMID: 34485945
A general protocol for the experimental assessment of bacteriophage adaptation to new hosts is described. We use as a model system the lytic phage T7 and an strain modified to...