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Eoin N McNamee

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Articles 48
Citations 2120
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Recent Articles
1.
Flynn C, Markey G, Neudecker V, Farrelly C, Furuta G, Eltzschig H, et al.
J Immunol . 2024 Nov; 213(12):1869-1883. PMID: 39485006
Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood....
2.
Benson T, Markey G, Hammer J, Simerly L, Dzieciatkowska M, Jordan K, et al.
Mucosal Immunol . 2024 Sep; 18(1):105-120. PMID: 39343055
Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack...
3.
Czopik A, McNamee E, Vaughn V, Huang X, Bang I, Clark T, et al.
Nat Commun . 2024 Sep; 15(1):8042. PMID: 39271652
Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases. We hypothesize that HIF could be stabilized in CD4 T...
4.
Ryan S, Crowe L, Almeida Cruz S, Galbraith M, OBrien C, Hammer J, et al.
J Allergy Clin Immunol . 2024 Aug; 154(6):1472-1488. PMID: 39209164
Background: Investigating the contributory role that epithelial cell metabolism plays in allergic inflammation is a key factor to understanding what influences dysfunction and the pathogenesis of the allergic disease eosinophilic...
5.
Dunbar H, Hawthorne I, Tunstead C, McNamee E, Weiss D, Armstrong M, et al.
Cytotherapy . 2024 May; 26(10):1245-1251. PMID: 38819366
Background: Trained immunity results in long-term immunological memory, provoking a faster and greater immune response when innate immune cells encounter a secondary, often heterologous, stimulus. We have previously shown that...
6.
Dunbar H, Hawthorne I, McNamee E, Armstrong M, Donnelly S, English K
FASEB J . 2024 Mar; 38(6):e23576. PMID: 38530238
High level expression of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has been associated with severe asthma. The role of MIF and its functional promotor polymorphism in innate immune...
7.
Markey G, Ryan S, Furuta G, Menard-Katcher C, McNamee E, Masterson J
FASEB J . 2023 Dec; 38(1):e23358. PMID: 38050671
MicroRNA (miRNA)-mediated mRNA regulation directs many homeostatic and pathological processes, but how miRNAs coordinate aberrant esophageal inflammation during eosinophilic esophagitis (EoE) is poorly understood. Here, we report a deregulatory axis...
8.
Markey G, Donohoe C, McNamee E, Masterson J
Am J Physiol Gastrointest Liver Physiol . 2023 May; 325(1):G1-G13. PMID: 37129237
MicroRNAs (miRNAs) are a class of small endogenous RNA molecules between 18 and 25 nucleotides long. The primary function of miRNAs is in the posttranscriptional regulation of mRNA targets through...
9.
Gallagher C, Mac Mahon J, ONeill C, Cassidy F, Dunbar H, De Barra C, et al.
J Invest Dermatol . 2022 Dec; 143(6):1094-1097.e2. PMID: 36516909
No abstract available.
10.
Olli K, Rapp C, OConnell L, Collins C, McNamee E, Jensen O, et al.
Inflamm Bowel Dis . 2020 May; 26(9):1353-1367. PMID: 32385500
Background: The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria and maintaining intestinal homeostasis in health and disease. Some MGL defects allowing bacteria to directly...