Enrico M A Fassi
Overview
Explore the profile of Enrico M A Fassi including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
55
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Recent Articles
1.
Ciceri S, Fassi E, Vezzoli V, Bonomi M, Colombo D, Ferraboschi P, et al.
Eur J Med Chem
. 2024 Sep;
279:116903.
PMID: 39342681
Gonadotropin-releasing hormone (GnRH) is the main regulator of the reproductive system, acting on gonadotropic cells by binding to the GnRH1 receptor (GnRH1R). Traditionally, therapies targeting this receptor have relied on...
2.
Ratti A, Fassi E, Forlani F, Zangrossi M, Mori M, Cappitelli F, et al.
Antioxidants (Basel)
. 2023 Aug;
12(8).
PMID: 37627607
Biofilm-dwelling cells endure adverse conditions, including oxidative imbalances. The NADH:quinone oxidoreductase enzyme WrbA has a crucial role in the mechanism of action of antibiofilm molecules such as ellagic and salicylic...
3.
Ratti A, Fassi E, Forlani F, Mori M, Villa F, Cappitelli F, et al.
Pharmaceutics
. 2023 Jun;
15(6).
PMID: 37376205
Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in...
4.
Lammi C, Fassi E, Manenti M, Brambilla M, Conti M, Li J, et al.
J Med Chem
. 2023 Jun;
66(12):7943-7958.
PMID: 37261954
Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates circulating cholesterol levels. Consequently, the PCSK9 inhibition is a valuable therapeutic...
5.
Ciceri S, Colombo D, Fassi E, Ferraboschi P, Grazioso G, Grisenti P, et al.
Molecules
. 2023 May;
28(9).
PMID: 37175271
Elagolix sodium salt is the first marketed orally active non-peptide gonadotropin-releasing hormone receptor antagonist (GnRHR-ant) for the management of hormone dependent diseases, such as endometriosis and uterine fibroids. Despite its...
6.
Fassi E, Manenti M, Citarella A, Cas M, Casati S, Micale N, et al.
Molecules
. 2023 Mar;
28(5).
PMID: 36903597
The COVID-19 pandemic has given a strong impetus to the search for antivirals active on SARS-associated coronaviruses. Over these years, numerous vaccines have been developed and many of these are...
7.
Lammi C, Fassi E, Li J, Bartolomei M, Benigno G, Roda G, et al.
Pharmaceutics
. 2022 Mar;
14(3).
PMID: 35336039
(1) Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates the circulating cholesterol level. In this field, we discovered...
8.
Sgrignani J, Cecchinato V, Fassi E, DAgostino G, Garofalo M, Danelon G, et al.
J Med Chem
. 2021 Sep;
64(18):13439-13450.
PMID: 34510899
During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. The alarmin HMGB1 and the chemokine CXCL12, both released in the microenvironment, can...
9.
Cassiano C, Morretta E, Costantini M, Fassi E, Colombo G, Sattin S, et al.
Bioorg Chem
. 2021 Aug;
115:105258.
PMID: 34392176
Hsp90 (i.e., Heat shock protein 90) is a well-established therapeutic target for several diseases, ranging from misfolding-related disfunctions to cancer. In this framework, we have developed in recent years a...
10.
Sgrignani J, Fassi E, Lammi C, Roda G, Grazioso G
ChemMedChem
. 2020 Jun;
15(16):1601-1607.
PMID: 32558225
Proprotein convertase subtilisin/kexin 9 (PCSK9) is a notable target for the treatment of hypercholesterolemia because it regulates the population of the low-density lipoprotein receptor (LDLR) on liver cells. The PCSK9...