Enrico De Smaele
Overview
Explore the profile of Enrico De Smaele including associated specialties, affiliations and a list of published articles.
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Articles
76
Citations
3176
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Recent Articles
1.
Bordin F, Terriaca G, Apostolico A, Di Fiore A, Mir F, Bellardinelli S, et al.
Cell Death Discov
. 2024 Dec;
10(1):498.
PMID: 39695131
The transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness. Whether activated through canonical or...
2.
Bordone R, Ivy D, DAmico R, Barba M, Gaggianesi M, Di Pastena F, et al.
Oncogene
. 2024 Sep;
43(46):3349-3365.
PMID: 39306615
The MYC oncogene is frequently overexpressed in tumors and inhibition of its translation is considered an attractive therapeutic opportunity. Despite numerous reports proposing an internal ribosome entry site (IRES) within...
3.
Lospinoso Severini L, Loricchio E, Navacci S, Basili I, Alfonsi R, Bernardi F, et al.
Cell Death Differ
. 2023 Dec;
31(2):170-187.
PMID: 38062245
The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant pediatric brain tumor. The SHH-MB subgroup is...
4.
Arena A, Romeo M, Po A, Benedetti R, Gilardini Montani M, Gonnella R, et al.
Microbiol Spectr
. 2023 Oct;
11(6):e0263623.
PMID: 37882554
The novelty of this study lies in the fact that it shows that IRE1 alpha endoribonuclease inhibition by 4μ8C was able to counteract Epstein-Barr virus-driven lymphomagenesis in NOD SCID gamma...
5.
Molfetta R, Lecce M, Milito N, Putro E, Pietropaolo G, Marangio C, et al.
Cell Death Dis
. 2023 Sep;
14(9):616.
PMID: 37730723
Mast cells (MCs) are multifaceted innate immune cells often present in the tumor microenvironment (TME). Several recent findings support their contribution to the transition from chronic inflammation to cancer. However,...
6.
Abballe L, Alfano V, Antonacci C, Cefalo M, Cacchione A, Del Baldo G, et al.
Front Cell Dev Biol
. 2023 Mar;
11:990711.
PMID: 36923256
Development of the cerebellum is characterized by rapid proliferation of cerebellar granule cell precursors (GCPs) induced by paracrine stimulation of Sonic hedgehog (Shh) signaling from Purkinje cells, in the external...
7.
Citarella A, Catanzaro G, Besharat Z, Trocchianesi S, Barbagallo F, Gosti G, et al.
Cancers (Basel)
. 2023 Mar;
15(5).
PMID: 36900263
Colorectal cancer (CRC) is a leading cause of cancer-related mortality and chemoresistance is a major medical issue. The epithelial-to-mesenchymal transition (EMT) is the primary step in the emergence of the...
8.
Coni S, Bordone R, Ivy D, Yurtsever Z, Di Magno L, DAmico R, et al.
Cancer Lett
. 2023 Mar;
559:216120.
PMID: 36893894
A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC and its targets, including ornithine decarboxylase (ODC), a master regulator of polyamine metabolism. Elevated polyamines promote tumorigenesis...
9.
Petroni M, Fabretti F, Di Giulio S, Nicolis di Robilant V, La Monica V, Moretti M, et al.
Neuropathol Appl Neurobiol
. 2022 Jul;
48(6):e12837.
PMID: 35839783
Aims: Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the incidence of tumours, including medulloblastoma (MB). On the other hand, MRE11, RAD50 and NBS1 protein components...
10.
Bei R, Benvenuto M, Focaccetti C, Fazi S, Moretti M, Nardozi D, et al.
J Transl Med
. 2022 Jun;
20(1):286.
PMID: 35752861
Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM. Thus, molecules involved...