Lucia Di Marcotullio
Overview
Explore the profile of Lucia Di Marcotullio including associated specialties, affiliations and a list of published articles.
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89
Citations
2803
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Recent Articles
1.
Bordin F, Terriaca G, Apostolico A, Di Fiore A, Mir F, Bellardinelli S, et al.
Cell Death Discov
. 2024 Dec;
10(1):498.
PMID: 39695131
The transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness. Whether activated through canonical or...
2.
Bordone R, Ivy D, DAmico R, Barba M, Gaggianesi M, Di Pastena F, et al.
Oncogene
. 2024 Sep;
43(46):3349-3365.
PMID: 39306615
The MYC oncogene is frequently overexpressed in tumors and inhibition of its translation is considered an attractive therapeutic opportunity. Despite numerous reports proposing an internal ribosome entry site (IRES) within...
3.
Espinosa-Bustos C, Bertrand J, Villegas-Menares A, Guerrero S, Di Marcotullio L, Navacci S, et al.
Bioorg Chem
. 2024 Aug;
151:107681.
PMID: 39106711
Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the development and progression of pancreatic cancer. For this reason, blockade of Hh pathway by inhibitors targeting the...
4.
Kumar A, Larrea D, Pero M, Infante P, Conenna M, Shin G, et al.
iScience
. 2024 Jun;
27(6):109994.
PMID: 38883841
Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial fusion and tethering with the ER....
5.
Lospinoso Severini L, Loricchio E, Navacci S, Basili I, Alfonsi R, Bernardi F, et al.
Cell Death Differ
. 2023 Dec;
31(2):170-187.
PMID: 38062245
The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant pediatric brain tumor. The SHH-MB subgroup is...
6.
Quaglio D, Infante P, Cammarone S, Lamelza L, Conenna M, Ghirga F, et al.
Chemistry
. 2023 Aug;
29(62):e202302237.
PMID: 37565343
Natural products (NPs) are highly profitable pharmacological tools due to their chemical diversity and ability to modulate biological systems. Accessing new chemical entities while retaining the biological relevance of natural...
7.
Kumar A, Larrea D, Pero M, Infante P, Conenna M, Shin G, et al.
bioRxiv
. 2023 Mar;
PMID: 36993604
Acetylated microtubules play key roles in the regulation of mitochondria dynamics. It has however remained unknown if the machinery controlling mitochondria dynamics functionally interacts with the alpha-tubulin acetylation cycle. Mitofusin-2...
8.
Coni S, Bordone R, Ivy D, Yurtsever Z, Di Magno L, DAmico R, et al.
Cancer Lett
. 2023 Mar;
559:216120.
PMID: 36893894
A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC and its targets, including ornithine decarboxylase (ODC), a master regulator of polyamine metabolism. Elevated polyamines promote tumorigenesis...
9.
Lucarini V, Melaiu O, DAmico S, Pastorino F, Tempora P, Scarsella M, et al.
J Exp Clin Cancer Res
. 2022 Nov;
41(1):326.
PMID: 36397148
Background: Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of selected immunogenic drugs...
10.
Petroni M, Fabretti F, Di Giulio S, Nicolis di Robilant V, La Monica V, Moretti M, et al.
Neuropathol Appl Neurobiol
. 2022 Jul;
48(6):e12837.
PMID: 35839783
Aims: Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the incidence of tumours, including medulloblastoma (MB). On the other hand, MRE11, RAD50 and NBS1 protein components...