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Emmanuel Van Obberghen

Explore the profile of Emmanuel Van Obberghen including associated specialties, affiliations and a list of published articles. Areas
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Articles 60
Citations 1995
Followers 0
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Recent Articles
1.
Poet M, Doyen D, Van Obberghen E, Jarretou G, Bouret Y, Counillon L
Front Physiol . 2022 Aug; 13:907587. PMID: 35910559
Na/H exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells. Following the cloning...
2.
Dumortier O, Fabris G, Pisani D, Casamento V, Gautier N, Hinault C, et al.
J Endocrinol . 2019 Nov; 244(1):189-200. PMID: 31697642
Enhanced beta cell glycolytic and oxidative metabolism are necessary for glucose-induced insulin secretion. While several microRNAs modulate beta cell homeostasis, miR-375 stands out as it is highly expressed in beta...
3.
Fabris G, Dumortier O, Pisani D, Gautier N, Van Obberghen E
Cell Death Dis . 2019 Jul; 10(8):566. PMID: 31332188
In an adult healthy liver, hepatocytes are in a quiescent stage unless a physical injury, such as ablation, or a toxic attack occur. Indeed, to maintain their crucial organismal homeostatic...
4.
Roger E, Dumortier O, Pisani D, Gautier N, Van Obberghen E, Hinault C
Biochim Biophys Acta Mol Basis Dis . 2019 Jun; 1865(9):2393-2402. PMID: 31152866
MicroRNAs (miRNAs) are important modulators of thermogenic brown adipose tissue (BAT). They have been involved in its differentiation and hence its functioning. While different regulators of the miRNA machinery have...
5.
Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, et al.
Cancers (Basel) . 2019 Feb; 11(2). PMID: 30795607
It is generally accepted that carcinogenesis and aging are two biological processes, which are known to be associated. Notably, the frequency of certain cancers (including lung cancer), increases significantly with...
6.
Sanchez-Parra C, Jacovetti C, Dumortier O, Lee K, Peyot M, Guay C, et al.
Diabetes . 2018 Aug; 67(11):2254-2267. PMID: 30115652
Pancreatic β-cell expansion throughout the neonatal period is essential to generate the appropriate mass of insulin-secreting cells required to maintain blood glucose homeostasis later in life. Hence, defects in this...
7.
Wagner R, Hakaste L, Ahlqvist E, Heni M, Machann J, Schick F, et al.
Diabetes . 2016 Dec; 66(5):1373-1379. PMID: 27986831
Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes....
8.
Dumortier O, Roger E, Pisani D, Casamento V, Gautier N, Lebrun P, et al.
Diabetes . 2016 Dec; 66(3):627-639. PMID: 27927722
Epidemiological and animal studies show that deleterious maternal environments predispose aging offspring to metabolic disorders and type 2 diabetes. Young progenies in a rat model of maternal low-protein (LP) diet...
9.
Pisani D, Dumortier O, Beranger G, Casamento V, Ghandour R, Giroud M, et al.
Adipocyte . 2016 Jul; 5(2):186-95. PMID: 27386154
Human brown adipocytes are able to burn fat and glucose and are now considered as a potential strategy to treat obesity, type 2 diabetes and metabolic disorders. Besides their thermogenic...
10.
Lopez P, Wagner K, Hofman P, Van Obberghen E
Mol Cell Biol . 2016 Mar; 36(10):1480-93. PMID: 26976645
RNA activation (RNAa) is a gene regulation process in which promoter-targeted short double-stranded RNAs (dsRNAs) or microRNAs (miRs) induce target gene expression at the transcriptional level. Here, we investigate the...