Emmanuel Normant
Overview
Explore the profile of Emmanuel Normant including associated specialties, affiliations and a list of published articles.
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25
Citations
989
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0
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Recent Articles
1.
Ribeiro M, Profitos-Peleja N, Santos J, Blecua P, Reyes-Garau D, Armengol M, et al.
Front Immunol
. 2023 May;
14:1130052.
PMID: 37153563
Background: Immunotherapy-based regimens have considerably improved the survival rate of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decades; however, most disease subtypes remain almost incurable. TG-1801, a bispecific antibody...
2.
3.
Yin Y, Athanasiadis P, Karlsen L, Urban A, Xu H, Murali I, et al.
Clin Cancer Res
. 2022 Aug;
28(20):4444-4455.
PMID: 35998013
Purpose: PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic leukemia (CLL). Although patients may show an initial response to these therapies, development of treatment intolerance or resistance remain clinical...
4.
Ribeiro M, Reyes-Garau D, Vinyoles M, Profitos Peleja N, Santos J, Armengol M, et al.
Clin Cancer Res
. 2021 Sep;
27(23):6591-6601.
PMID: 34551904
Purpose: Despite the remarkable activity of BTK inhibitors (BTKi) in relapsed B-cell non-Hodgkin lymphoma (B-NHL), no clinically-relevant biomarker has been associated to these agents so far. The relevance of phosphoproteomic...
5.
Janovska P, Normant E, Miskin H, Bryja V
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33261128
The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act...
6.
Peluso M, Adam A, Armet C, Zhang L, OConnor R, Lee B, et al.
J Immunother Cancer
. 2020 Apr;
8(1).
PMID: 32345627
Background: CD47 is a broadly expressed cell surface glycoprotein associated with immune evasion. Interaction with the inhibitory receptor signal regulatory protein alpha (SIRPα), primarily expressed on myeloid cells, normally serves...
7.
Vaswani R, Gehling V, Dakin L, Cook A, Nasveschuk C, Duplessis M, et al.
J Med Chem
. 2016 Oct;
59(21):9928-9941.
PMID: 27739677
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of...
8.
Albrecht B, Gehling V, Hewitt M, Vaswani R, Cote A, LeBlanc Y, et al.
J Med Chem
. 2016 Jan;
59(4):1330-9.
PMID: 26815195
In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues on chromatin has emerged as a promising approach to...
9.
Gehling V, Vaswani R, Nasveschuk C, Duplessis M, Iyer P, Balasubramanian S, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3644-9.
PMID: 26189078
The discovery and optimization of a series of small molecule EZH2 inhibitors is described. Starting from dimethylpyridone HTS hit (2), a series of indole-based EZH2 inhibitors were identified. Biochemical potency...
10.
Bradley W, Arora S, Busby J, Balasubramanian S, Gehling V, Nasveschuk C, et al.
Chem Biol
. 2014 Dec;
21(11):1463-75.
PMID: 25457180
The histone lysine methyltransferase (MT) Enhancer of Zeste Homolog 2 (EZH2) is considered an oncogenic driver in a subset of germinal center B-cell-like diffuse large B cell lymphoma (GCB-DLBCL) and...