Emanuela Capota
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Explore the profile of Emanuela Capota including associated specialties, affiliations and a list of published articles.
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9
Citations
525
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Recent Articles
1.
Kakde B, Capota E, Kohler J, Tambar U
J Org Chem
. 2021 Oct;
86(24):18257-18264.
PMID: 34618463
We recently reported the incorporation of diazirine photo-cross-linkers onto the -GlcNAc posttranslational modification in mammalian cells, enabling the identification of binding partners of -GlcNAcylated proteins. Unfortunately, the syntheses of the...
2.
Wu H, Shajahan A, Yang J, Capota E, Wands A, Arthur C, et al.
Cell Chem Biol
. 2021 Jul;
29(1):84-97.e8.
PMID: 34331854
N-glycans are displayed on cell-surface proteins and can engage in direct binding interactions with membrane-bound and secreted glycan-binding proteins (GBPs). Biochemical identification and characterization of glycan-mediated interactions is often made...
3.
Capota E, Wu H, Kohler J
Curr Protoc
. 2021 Jul;
1(7):e201.
PMID: 34288588
This protocol enables identification of the interaction partners of O-GlcNAcylated proteins. The method involves the introduction of the diazirine photocrosslinker onto the O-GlcNAc modification within living cells. The photocrosslinker is...
4.
Wang Y, Chen Y, Wang C, Yang M, Wang Y, Bao L, et al.
Nat Commun
. 2021 May;
12(1):2954.
PMID: 34012010
How cancer cells cope with high levels of replication stress during rapid proliferation is currently unclear. Here, we show that macrophage migration inhibitory factor (MIF) is a 3' flap nuclease...
5.
Winterton S, Capota E, Wang X, Chen H, Mallipeddi P, Williams N, et al.
J Med Chem
. 2018 Jun;
61(12):5199-5221.
PMID: 29869888
Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation....
6.
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting T, et al.
Science
. 2017 Mar;
356(6336).
PMID: 28302793
Indisulam is an aryl sulfonamide drug with selective anticancer activity. Its mechanism of action and the basis for its selectivity have so far been unknown. Here we show that indisulam...
7.
Han T, Goralski M, Capota E, Padrick S, Kim J, Xie Y, et al.
Nat Chem Biol
. 2016 May;
12(7):511-5.
PMID: 27182663
CD437 is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, through an unknown mechanism. We used a forward-genetic strategy to discover mutations...
8.
Pieper A, Xie S, Capota E, Estill S, Zhong J, Long J, et al.
Cell
. 2010 Jul;
142(1):39-51.
PMID: 20603013
An in vivo screen was performed in search of chemicals capable of enhancing neuron formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced neuron formation...
9.
Zhao H, Negash L, Wei Q, LaCour T, Estill S, Capota E, et al.
J Am Chem Soc
. 2008 Sep;
130(42):13864-6.
PMID: 18811162
We are developing methods that restrict the conformational mobility of peptides and related heteropolymers while simultaneously altering their properties. Our experiments occur as processes wherein a conserved, lipophilic reagent is...