Andrew A Pieper
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Explore the profile of Andrew A Pieper including associated specialties, affiliations and a list of published articles.
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106
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2704
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Recent Articles
1.
Feng Y, Cao S, Shi Y, Sun A, Flanagan M, Leverenz J, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14595.
PMID: 39985481
Introduction: Human herpesvirus (HHV) has been linked to Alzheimer's disease (AD), but the underlying mechanisms remain unknown. Methods: We leveraged functional genomics data from Religious Orders Study or the Rush...
2.
Ren Y, Pieper A, Cheng F
Neurotherapeutics
. 2025 Feb;
:e00553.
PMID: 39965994
Alzheimer's disease (AD) presents significant challenges in drug discovery and development due to its complex and poorly understood pathology and etiology. Digital twins (DTs) are recently developed virtual real-time representations...
3.
Dou L, Xu Z, Xu J, Zang C, Su C, Pieper A, et al.
NPJ Parkinsons Dis
. 2025 Jan;
11(1):22.
PMID: 39837893
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. However, current treatments only manage symptoms and lack the ability to slow or prevent disease progression. We utilized a systems...
4.
Xu J, Song W, Xu Z, Danziger M, Karavani E, Zang C, et al.
Alzheimers Dement
. 2024 Dec;
21(1):e14373.
PMID: 39641322
Introduction: High microglial heterogeneities hinder the development of microglia-targeted treatment for Alzheimer's disease (AD). Methods: We integrated 0.7 million single-nuclei RNA-sequencing transcriptomes from human brains using a variational autoencoder. We...
5.
Yu M, Xu J, Dutta R, Trapp B, Pieper A, Cheng F
NPJ Syst Biol Appl
. 2024 Nov;
10(1):128.
PMID: 39500920
Amyotrophic Lateral Sclerosis (ALS) is a devastating, immensely complex neurodegenerative disease by lack of effective treatments. We developed a network medicine methodology via integrating human brain multi-omics data to prioritize...
6.
Dou L, Xu Z, Xu J, Su C, Pieper A, Zhu X, et al.
Res Sq
. 2024 Nov;
PMID: 39483867
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. However, current treatments are directed at symptoms and lack ability to slow or prevent disease progression. Large-scale genome-wide association studies...
7.
Hong N, Chaplin A, Di L, Ravodina A, Bevan G, Gao H, et al.
Cell Rep
. 2024 Oct;
43(11):114911.
PMID: 39466775
Current pharmacologic treatments for atherosclerosis do not completely protect patients; additional protection can be achieved by dietary modifications, such as a low-cholesterol/low-fat diet (LCLFD), that mediate plaque stabilization and inflammation...
8.
Nishiguchi T, Yamanishi K, Patel S, Malicoat J, Phuong N, Seki T, et al.
Transl Psychiatry
. 2024 Oct;
14(1):413.
PMID: 39358319
Delirium is a multifactorial medical condition of waxing and waning impairment across various domains of mental functioning over time. Importantly, delirium is also one of the greatest risk factors for...
9.
Feng Y, Yang X, Hou Y, Zhou Y, Leverenz J, Eng C, et al.
Alzheimers Dement
. 2024 Oct;
20(11):7495-7517.
PMID: 39356058
Introduction: Transposable element (TE) dysregulation is associated with neuroinflammation in Alzheimer's disease (AD) brains. Yet, TE quantitative trait loci (teQTL) have not been well characterized in human aged brains with...
10.
Sridharan P, Koh Y, Miller E, Hu D, Chakraborty S, Tripathi S, et al.
Cell Rep Med
. 2024 Sep;
5(9):101715.
PMID: 39241772
Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in...