Deepak Nijhawan
Overview
Explore the profile of Deepak Nijhawan including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
1692
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Recent Articles
1.
Singh S, Gleason C, Fang M, Laimon Y, Khivansara V, Xie S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211113
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with...
2.
Theodoropoulos P, Guo H, Wang W, Crossley E, Rivera Cancel G, Fang M, et al.
ACS Chem Biol
. 2024 Jun;
19(6):1339-1350.
PMID: 38829020
N-Pyridinylthiophene carboxamide (compound 21) displays activity against peripheral nerve sheath cancer cells and mouse xenografts by an unknown mechanism. Through medicinal chemistry, we identified a more active derivative, compound ,...
3.
Wang H, Nguyen T, Sternisha A, Carroll C, Cross B, Morlock L, et al.
J Med Chem
. 2024 May;
67(11):9277-9301.
PMID: 38804887
We recently discovered a novel N-aryl tetracyclic dicarboximide MM0299 () with robust activity against glioma stem-like cells that potently and selectively inhibits lanosterol synthase leading to the accumulation of the...
4.
Tao Y, Budhipramono A, Huang J, Fang M, Xie S, Kim J, et al.
Cell Chem Biol
. 2023 Nov;
31(1):139-149.e14.
PMID: 37967558
A novel class of benzoxaboroles was reported to induce cancer cell death but the mechanism was unknown. Using a forward genetics platform, we discovered mutations in cleavage and polyadenylation specific...
5.
Nguyen T, Fang M, Kim J, Wang B, Lin E, Khivansara V, et al.
Cell Chem Biol
. 2023 Aug;
30(11):1453-1467.e8.
PMID: 37607550
Orphan cytotoxins are small molecules for which the mechanism of action (MoA) is either unknown or ambiguous. Unveiling the mechanism of these compounds may lead to useful tools for biological...
6.
Sun Y, Baechler S, Zhang X, Kumar S, Factor V, Arakawa Y, et al.
Nat Commun
. 2023 Jun;
14(1):3762.
PMID: 37353483
Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human...
7.
Nguyen T, Fang M, Kim J, Wang B, Lin E, Khivansara V, et al.
bioRxiv
. 2023 Mar;
PMID: 36865268
Orphan cytotoxins are small molecules for which the mechanism of action (MoA) is either unknown or ambiguous. Unveiling the mechanism of these compounds may lead to useful tools for biological...
8.
Nguyen T, Wang W, Sternisha A, Corley C, Wang H, Wang X, et al.
Cell Chem Biol
. 2023 Feb;
30(2):214-229.e18.
PMID: 36758549
Glioblastoma (GBM) is an aggressive adult brain cancer with few treatment options due in part to the challenges of identifying brain-penetrant drugs. Here, we investigated the mechanism of MM0299, a...
9.
Zhou J, Simon J, Liao C, Zhang C, Hu L, Zurlo G, et al.
Mol Cell
. 2022 Jun;
82(16):3030-3044.e8.
PMID: 35764091
Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma (ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased siRNA screen of 2-oxoglutarate (2-OG)-dependent...
10.
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde L, et al.
Sci Adv
. 2021 Nov;
7(47):eabj5405.
PMID: 34788094
Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a MYC-driven cancer characterized by splicing dysregulation...