Ellen M Unterwald
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Explore the profile of Ellen M Unterwald including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Gunaratne G, Brailoiu E, He S, Unterwald E, Patel S, Slama J, et al.
Sci Signal
. 2021 Mar;
14(675).
PMID: 33758061
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action...
12.
Barr J, Brailoiu G, Unterwald E, Brailoiu E
Methods Mol Biol
. 2021 Mar;
2367:123-135.
PMID: 33689166
We report here the method of visualization of brain microcirculation and assessment of blood-brain barrier (BBB) permeability changes using the miniature integrated fluorescence microscope (i.e., miniscope) technology in awake, freely...
13.
Connelly K, Wolsh C, Barr J, Bauder M, Hausch F, Unterwald E
Neurobiol Stress
. 2020 Dec;
13:100232.
PMID: 33344688
Cocaine use and withdrawal prompt stress system responses. Stress and the negative affective state produced by cocaine withdrawal are major triggers for relapse. FKBP5 is a co-chaperone of the glucocorticoid...
14.
Nocito C, Lubinsky C, Hand M, Khan S, Patel T, Seliga A, et al.
Front Immunol
. 2020 Oct;
11:573677.
PMID: 33042154
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations of human SLE, often causing depression. Interferon-α (IFNα)...
15.
Swinford-Jackson S, OBrien C, Kenny P, Vanderschuren L, Unterwald E, Pierce R
Cold Spring Harb Perspect Med
. 2020 Jul;
11(11).
PMID: 32601131
There are currently effective Food and Drug Administration (FDA)-approved therapies for alcohol, nicotine, and opioid use disorders. This article will review the development of eight compounds used in the treatment...
16.
Barr J, Unterwald E
Biochim Biophys Acta Mol Cell Res
. 2020 May;
1867(9):118746.
PMID: 32454064
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase implicated in numerous physiological processes and cellular functions through its ability to regulate the function of many proteins, including transcription factors and...
17.
Connelly K, Unterwald E
Int J Neuropsychopharmacol
. 2019 Dec;
23(2):117-124.
PMID: 31867624
Background: Cocaine withdrawal activates stress systems. Females are more vulnerable to relapse to cocaine use and more sensitive to withdrawal-induced negative affect. Delta opioid receptors modulate anxiety-like behavior during cocaine...
18.
Barr J, Shi X, Zaykaner M, Unterwald E
Neuroscience
. 2019 Nov;
425:101-111.
PMID: 31783102
The ventral hippocampus is a component of the neural circuitry involved with context-associated memory for reward and generation of appropriate behavioral responses to context. Glycogen synthase kinase 3 beta (GSK3β)...
19.
Barr J, Brailoiu G, Abood M, Rawls S, Unterwald E, Brailoiu E
Drug Alcohol Depend
. 2019 Nov;
206:107637.
PMID: 31734036
Background: Cocaine has a variety of negative effects on the central nervous system, including reports of decreased barrier function of brain microvascular endothelial cells. However, few studies have directly shown...
20.
Shi X, Barr J, von Weltin E, Wolsh C, Unterwald E
J Pharmacol Exp Ther
. 2019 Aug;
371(2):339-347.
PMID: 31420527
Previous research has demonstrated that activity of glycogen synthase kinase-3 (GSK3) is necessary for the rewarding effects of cocaine. In the present study, a conditional GSK3 gene knockdown model was...