Ellen C Moore
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Explore the profile of Ellen C Moore including associated specialties, affiliations and a list of published articles.
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11
Citations
421
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Recent Articles
1.
Friedman J, Moore E, Zolkind P, Robbins Y, Clavijo P, Sun L, et al.
Clin Cancer Res
. 2019 Oct;
26(3):679-689.
PMID: 31645352
Purpose: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic...
2.
Clavijo P, Friedman J, Robbins Y, Moore E, Smith E, Zauderer M, et al.
Cancer Immunol Res
. 2018 Dec;
7(2):282-291.
PMID: 30514791
Tumor infiltration by immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs), causes resistance to immunotherapy. Semaphorin4D, originally characterized for its axonal guidance properties, also contributes to endothelial cell migration...
3.
Friedman J, Morisada M, Sun L, Moore E, Padget M, Hodge J, et al.
J Immunother Cancer
. 2018 Jun;
6(1):59.
PMID: 29925431
Background: Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing...
4.
Moore E, Sun L, Clavijo P, Friedman J, Harford J, Saleh A, et al.
Oncoimmunology
. 2018 Jun;
7(7):e1404216.
PMID: 29900037
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration...
5.
Clavijo P, Moore E, Chen J, Davis R, Friedman J, Kim Y, et al.
Oncotarget
. 2017 Sep;
8(34):55804-55820.
PMID: 28915554
Purpose: Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination...
6.
Morisada M, Moore E, Hodge R, Friedman J, Cash H, Hodge J, et al.
Oral Oncol
. 2017 Jul;
71:87-94.
PMID: 28688697
Objectives: Determine if direct tumor cell cytotoxicity, antigen release, and susceptibility to T-lymphocyte killing following radiation treatment is dose-dependent. Materials And Methods: Mouse oral cancer cells were engineered to express...
7.
Davis R, Moore E, Clavijo P, Friedman J, Cash H, Chen Z, et al.
Cancer Res
. 2017 Apr;
77(10):2607-2619.
PMID: 28364000
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of...
8.
Moore E, Cash H, Caruso A, Uppaluri R, Hodge J, Van Waes C, et al.
Cancer Immunol Res
. 2016 Apr;
4(7):611-20.
PMID: 27076449
Significant subsets of patients with oral cancer fail to respond to single-agent programmed death (PD) blockade. Syngeneic models of oral cancer were used to determine if blocking oncogenic signaling improved...
9.
Nesterovitch A, Gyorfy Z, Hoffman M, Moore E, Elbuluk N, Tryniszewska B, et al.
Am J Pathol
. 2011 Mar;
178(4):1434-41.
PMID: 21406173
We have found a B2 repeat insertion in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6) in a mouse that developed a skin disorder with clinical and histopathological...
10.
Salimnia H, Moore E, Crane L, MacArthur R, Fairfax M
J Clin Microbiol
. 2005 Sep;
43(9):4635-9.
PMID: 16145119
The Roche COBAS AMPLICOR human immunodeficiency virus type 1 (HIV-1) Monitor (version 1.5) standard and ultrasensitive viral load assays often gave discordant results, with viral loads from the standard assay...