Elissa W P Wong
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Explore the profile of Elissa W P Wong including associated specialties, affiliations and a list of published articles.
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40
Citations
1558
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Recent Articles
1.
Wang N, Pachai M, Li D, Lee C, Warda S, Khudoynazarova M, et al.
Nat Genet
. 2025 Jan;
57(1):165-179.
PMID: 39806204
Members of the KMT2C/D-KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium...
2.
Wong E, Sahin M, Yang R, Lee U, Zhan Y, Misra R, et al.
bioRxiv
. 2024 Jun;
PMID: 38895201
Transposable elements (TEs) are abundant in the human genome, and they provide the sources for genetic and functional diversity. The regulation of TEs expression and their functional consequences in physiological...
3.
Li D, Zhan Y, Wang N, Tang F, Lee C, Bayshtok G, et al.
Sci Adv
. 2023 Apr;
9(14):eadc9446.
PMID: 37018402
The mechanisms underlying -driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this phenotype. We generated a genetically engineered mouse with...
4.
Patel A, Warda S, Maag J, Misra R, Miranda-Roman M, Pachai M, et al.
Cancer Discov
. 2022 Jul;
12(9):2120-2139.
PMID: 35789380
Significance: PRC2 inactivation drives oncogenesis in various cancers, but therapeutically targeting PRC2 loss has remained challenging. Here we show that PRC2-inactivating mutations set up a tumor context-specific liability for therapeutic...
5.
Augello M, Liu D, Deonarine L, Robinson B, Huang D, Stelloo S, et al.
Cancer Cell
. 2019 May;
35(5):817-819.
PMID: 31085180
No abstract available.
6.
Liu E, Martinez-Fundichely A, Diaz B, Aronson B, Cuykendall T, MacKay M, et al.
Cell Syst
. 2019 May;
8(5):446-455.e8.
PMID: 31078526
Recent studies have shown that mutations at non-coding elements, such as promoters and enhancers, can act as cancer drivers. However, an important class of non-coding elements, namely CTCF insulators, has...
7.
Augello M, Liu D, Deonarine L, Robinson B, Huang D, Stelloo S, et al.
Cancer Cell
. 2019 Apr;
35(4):603-617.e8.
PMID: 30930119
Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and reasons for its tissue-specific...
8.
Ran L, Chen Y, Sher J, Wong E, Murphy D, Zhang J, et al.
Cancer Discov
. 2017 Nov;
8(2):234-251.
PMID: 29162563
The cellular context that integrates upstream signaling and downstream nuclear response dictates the oncogenic behavior and shapes treatment responses in distinct cancer types. Here, we uncover that in gastrointestinal stromal...
9.
Shukla S, Cyrta J, Murphy D, Walczak E, Ran L, Agrawal P, et al.
Cancer Cell
. 2017 Nov;
32(6):792-806.e7.
PMID: 29153843
Prostate cancer exhibits a lineage-specific dependence on androgen signaling. Castration resistance involves reactivation of androgen signaling or activation of alternative lineage programs to bypass androgen requirement. We describe an aberrant...
10.
Tung K, Harakal J, Qiao H, Rival C, Li J, Paul A, et al.
J Clin Invest
. 2017 Feb;
127(3):1046-1060.
PMID: 28218625
Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens...