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Elisa Mitiko Kawamoto

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Articles 37
Citations 772
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Recent Articles
1.
Rodrigues B, Silva J, Kawamoto E
Cerebellum . 2025 Feb; 24(2):52. PMID: 39985593
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication and restricted and repetitive patterns of behavior. In addition, individuals diagnosed with ASD may also present...
2.
Silva J, Rodrigues B, Kawamoto E
Brain Struct Funct . 2024 Dec; 230(1):7. PMID: 39688729
Serotonin (5-HT) is an important neurotransmitter for cognition and neurogenesis in the dentate gyrus (DG), which occurs via movement stimulation such as physical activity. Brain 5-HT function changes secondary to...
3.
Souza Lima T, Raissa Ribeiro M, de Brito M, Kawamoto E
Neuroscience . 2024 Sep; 560:1-10. PMID: 39293729
Type 1 diabetes mellitus (T1D) is associated with cognitive impairments in humans. A well-established animal model of T1D is induced through the administration of streptozotocin (STZ), a glucose analog that...
4.
Dos Santos G, Cararo-Lopes M, Possebom I, de Sa Lima L, Scavone C, Kawamoto E
Neuropharmacology . 2024 Aug; 258:110097. PMID: 39094831
Aging is characterized by a functional decline in several physiological systems. α-Klotho-hypomorphic mice (Kl) exhibit accelerated aging and cognitive decline. We evaluated whether male and female α-Klotho-hypomorphic mice show changes...
5.
Orellana A, Mazucanti C, Dos Anjos L, de Sa Lima L, Kawamoto E, Scavone C
Sci Rep . 2023 Sep; 13(1):15080. PMID: 37699938
Klotho is an antiaging protein, and its levels decline with age and chronic stress. The exogenous administration of Klotho can enhance cognitive performance in mice and negatively modulate the Insulin/IGF1/PI3K/AKT...
6.
Leite J, Orellana A, Andreotti D, Matumoto A, de Souza Ports N, de Sa Lima L, et al.
Biomedicines . 2023 May; 11(4). PMID: 37189795
Ouabain (OUA) is a cardiotonic steroid that modulates Na+, K+ -ATPase activity. OUA has been identified as an endogenous substance that is present in human plasma, and it has been...
7.
Kinoshita P, Orellana A, Andreotti D, de Souza G, Prudente de Mello N, de Sa Lima L, et al.
Biomedicines . 2022 Nov; 10(11). PMID: 36428505
Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na/K-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain. TNF...
8.
Nakao V, Mazucanti C, de Sa Lima L, de Mello P, de Souza Ports N, Kinoshita P, et al.
Sci Rep . 2022 Nov; 12(1):18884. PMID: 36344527
The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB...
9.
Leite J, Pocas E, Maia G, Barbosa L, Quintas L, Kawamoto E, et al.
Front Pharmacol . 2022 Sep; 13:916312. PMID: 36105192
The Na/K-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of...
10.
Spina Nagy G, Kawamoto E, Bridi J
Neurosci Lett . 2021 Jun; 759:136015. PMID: 34111509
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates several cellular processes including survival, proliferation, and metabolism. In the brain, PTEN is a key modulator of synaptic function, and...