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Diana Zukas Andreotti

Explore the profile of Diana Zukas Andreotti including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 186
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Recent Articles
1.
Leite J, Orellana A, Andreotti D, Matumoto A, de Souza Ports N, de Sa Lima L, et al.
Biomedicines . 2023 May; 11(4). PMID: 37189795
Ouabain (OUA) is a cardiotonic steroid that modulates Na+, K+ -ATPase activity. OUA has been identified as an endogenous substance that is present in human plasma, and it has been...
2.
Kinoshita P, Orellana A, Andreotti D, de Souza G, Prudente de Mello N, de Sa Lima L, et al.
Biomedicines . 2022 Nov; 10(11). PMID: 36428505
Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na/K-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain. TNF...
3.
Santos W, Montoni F, Eichler R, Arcos S, Andreotti D, Kisaki C, et al.
J Proteomics . 2022 Feb; 258:104530. PMID: 35182786
Snake envenomation is a common but neglected disease that affects millions of people around the world annually. Among venomous snake species in Brazil, the tropical rattlesnake (Crotalus durissus terrificus) accounts...
4.
Prudente de Mello N, Andreotti D, Orellana A, Scavone C, Kawamoto E
Sci Rep . 2020 Nov; 10(1):20189. PMID: 33214645
Sex differences are considered predictive factors in the development of several neurological diseases, which are also known to coincide with impaired phosphoinositide 3-kinase (PI3K)-AKT pathway activity, an essential signaling cascade...
5.
Andreotti D, Silva J, Matumoto A, Orellana A, de Mello P, Kawamoto E
Front Nutr . 2020 Aug; 7:94. PMID: 32850930
The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism...
6.
Montoni F, Andreotti D, Eichler R, da Silva Santos W, Kisaki C, Arcos S, et al.
J Proteomics . 2020 Apr; 221:103779. PMID: 32272218
Snake envenomation is responsible for more than 130,000 deaths worldwide. In Brazil, the Crotalus rattlesnake is responsible for the second largest number of accidental snake bites in the country. Although...
7.
Orellana A, Leite J, Kinoshita P, Vasconcelos A, Andreotti D, de Sa Lima L, et al.
Neuropharmacology . 2018 Aug; 140:260-274. PMID: 30099050
Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role...
8.
Orellana A, Vasconcelos A, Leite J, de Sa Lima L, Andreotti D, Munhoz C, et al.
Aging (Albany NY) . 2015 Dec; 7(12):1094-111. PMID: 26647069
Aging is a multifactorial process associated with an increased susceptibility to neurodegenerative disorders which can be related to chronic inflammation. Chronic inflammation, however, can be characterized by the persistent elevated...
9.
Mazucanti C, Cabral-Costa J, Vasconcelos A, Andreotti D, Scavone C, Kawamoto E
Curr Top Med Chem . 2015 Jun; 15(21):2116-38. PMID: 26059361
Recent data from epidemiologic studies have shown that the majority of the public health costs are related to age-related disorders, and most of these diseases can lead to neuronal death....
10.
Degaspari S, Tzanno-Martins C, Fujihara C, Zatz R, Branco-Martins J, Viel T, et al.
PLoS One . 2015 May; 10(5):e0125271. PMID: 25961830
Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) and may play a role in the development...