Eliot L Coffey
Overview
Explore the profile of Eliot L Coffey including associated specialties, affiliations and a list of published articles.
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7
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2663
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Recent Articles
1.
Li C, Coffey E, DallAgnese A, Hannett N, Tang X, Henninger J, et al.
Nature
. 2020 Jul;
586(7829):440-444.
PMID: 32698189
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing. Mutations in the MECP2 gene cause the progressive...
2.
Klein I, Boija A, Afeyan L, Hawken S, Fan M, DallAgnese A, et al.
Science
. 2020 Jun;
368(6497):1386-1392.
PMID: 32554597
The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are...
3.
Zamudio A, DallAgnese A, Henninger J, Manteiga J, Afeyan L, Hannett N, et al.
Mol Cell
. 2019 Sep;
76(5):753-766.e6.
PMID: 31563432
The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular...
4.
Shrinivas K, Sabari B, Coffey E, Klein I, Boija A, Zamudio A, et al.
Mol Cell
. 2019 Aug;
75(3):549-561.e7.
PMID: 31398323
Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in...
5.
Canzio D, Nwakeze C, Horta A, Rajkumar S, Coffey E, Duffy E, et al.
Cell
. 2019 Apr;
177(3):639-653.e15.
PMID: 30955885
Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here, we show that Pcdhα...
6.
Boija A, Klein I, Sabari B, DallAgnese A, Coffey E, Zamudio A, et al.
Cell
. 2018 Nov;
175(7):1842-1855.e16.
PMID: 30449618
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the...
7.
Sabari B, DallAgnese A, Boija A, Klein I, Coffey E, Shrinivas K, et al.
Science
. 2018 Jun;
361(6400).
PMID: 29930091
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we...