Krishna Shrinivas
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Explore the profile of Krishna Shrinivas including associated specialties, affiliations and a list of published articles.
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13
Citations
3808
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Recent Articles
1.
Schede H, Natarajan P, Chakraborty A, Shrinivas K
Nat Commun
. 2023 Jul;
14(1):4152.
PMID: 37438363
Condensation by phase separation has recently emerged as a mechanism underlying many nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic acids and proteins, localize to specific genomic regions,...
2.
Natarajan P, Shrinivas K, Chakraborty A
Biophys J
. 2023 Jun;
122(13):2757-2772.
PMID: 37277993
Long noncoding RNAs (lncRNAs) perform several important functions in cells including cis-regulation of transcription. Barring a few specific cases, the mechanisms underlying transcriptional regulation by lncRNAs remain poorly understood. Transcriptional...
3.
Lu W, Helou Y, Shrinivas K, Liou J, Au-Yeung B, Weiss A
Nat Immunol
. 2022 Dec;
24(1):136-147.
PMID: 36581712
Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP) by phospholipase C-γ (PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent thymocyte and T cell responses. PIP replenishment following...
4.
Shrinivas K, Brenner M
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34725154
Fluids in natural systems, like the cytoplasm of a cell, often contain thousands of molecular species that are organized into multiple coexisting phases that enable diverse and specific functions. How...
5.
Henninger J, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng M, et al.
Cell
. 2020 Dec;
184(1):207-225.e24.
PMID: 33333019
Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process...
6.
Klein I, Boija A, Afeyan L, Hawken S, Fan M, DallAgnese A, et al.
Science
. 2020 Jun;
368(6497):1386-1392.
PMID: 32554597
The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are...
7.
Shrinivas K, Sabari B, Coffey E, Klein I, Boija A, Zamudio A, et al.
Mol Cell
. 2019 Aug;
75(3):549-561.e7.
PMID: 31398323
Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in...
8.
Guo Y, Manteiga J, Henninger J, Sabari B, DallAgnese A, Hannett N, et al.
Nature
. 2019 Aug;
572(7770):543-548.
PMID: 31391587
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex. The large subunit of Pol ...
9.
Boija A, Klein I, Sabari B, DallAgnese A, Coffey E, Zamudio A, et al.
Cell
. 2018 Nov;
175(7):1842-1855.e16.
PMID: 30449618
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the...
10.
Gao A, Shrinivas K, Lepeudry P, Suzuki H, Sharp P, Chakraborty A
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):E11053-E11060.
PMID: 30404915
A hallmark of biological systems is that particular functions and outcomes are realized in specific contexts, such as when particular signals are received. One mechanism for mediating specificity is described...