Eliana S Armstrong
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Explore the profile of Eliana S Armstrong including associated specialties, affiliations and a list of published articles.
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13
Citations
319
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Recent Articles
1.
Connolly L, Riddle V, Cebrik D, Armstrong E, Miller L
Antimicrob Agents Chemother
. 2018 Jan;
62(4).
PMID: 29378708
Increasing antimicrobial resistance among uropathogens limits treatment options for patients with complicated urinary tract infection (cUTI). Plazomicin, a new aminoglycoside, has activity against multidrug-resistant , including isolates resistant to currently...
2.
Armstrong E, Mikulca J, Cloutier D, Bliss C, Steenbergen J
BMC Infect Dis
. 2016 Nov;
16(1):710.
PMID: 27887579
Background: Fluoroquinolones are a guideline-recommended therapy for complicated urinary tract infections, including pyelonephritis. Elevated drug concentrations of fluoroquinolones in the urine and therapy with high-dose levofloxacin are believed to overcome...
3.
Armstrong E, Farrell D, Palchak M, Steenbergen J
Antimicrob Agents Chemother
. 2015 Nov;
60(1):666-8.
PMID: 26552971
The in vitro activities of ceftolozane-tazobactam, meropenem, and metronidazole were determined against anaerobic organisms isolated from patients with complicated intraabdominal infections (cIAI) in global phase III studies. Ceftolozane-tazobactam activity was...
4.
Maianti J, Kanazawa H, Dozzo P, Matias R, Feeney L, Armstrong E, et al.
ACS Chem Biol
. 2014 Jul;
9(9):2067-73.
PMID: 25019242
Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity. Despite over three decades of speculation whether or not modulation of pKa is...
5.
Hanessian S, Giguere A, Grzyb J, Maianti J, Saavedra O, Aggen J, et al.
ACS Med Chem Lett
. 2014 Jun;
2(12):924-8.
PMID: 24900282
Deoxygenation of the diol groups in rings A and D of neomycin in combination with the introduction of an N1-(l)-HABA group in the 2-deoxystreptamine subunit (ring B) leads to a...
6.
Hanessian S, Maianti J, Matias R, Feeney L, Armstrong E
Org Lett
. 2011 Nov;
13(24):6476-9.
PMID: 22085292
Biosynthetically inspired manipulation of the antibiotic paromomycin led, in six high-yielding steps, to a ring A harboring an α,β-unsaturated 6'-aldehyde and an allylic 3'-methylcarbonate group. Tsuji deoxygenation in the presence...
7.
Tenover F, Tickler I, Armstrong E, Kubo A, Lopez S, Persing D, et al.
Int J Antimicrob Agents
. 2011 Aug;
38(4):352-4.
PMID: 21820877
The activity of ACHN-490 was evaluated against 493 meticillin-resistant Staphylococcus aureus (MRSA) isolates collected in 2009-2010 from 23 US hospitals. The MIC(50) and MIC(90) values (minimal inhibitory concentrations for 50%...
8.
Johansson H, Johansson M, Wong A, Armstrong E, Peterson E, Grant R, et al.
Appl Environ Microbiol
. 2011 May;
77(12):4223-5.
PMID: 21531830
The group II azoreductase BTI1 utilizes NADPH to directly cleave azo bonds in water-soluble azo dyes, including quenchers of fluorescence. Unexpectedly, optimal reduction was dye specific, ranging from a pH...
9.
Pankuch G, Lin G, Kubo A, Armstrong E, Appelbaum P, Kosowska-Shick K
Antimicrob Agents Chemother
. 2011 Feb;
55(5):2463-5.
PMID: 21282445
ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was...
10.
Armstrong E, Miller G
Curr Opin Microbiol
. 2010 Oct;
13(5):565-73.
PMID: 20932796
The challenge posed by increasing levels of drug-resistant bacteria world-wide is manifest, and must be dealt with both by new approaches to the use of existing antibiotics and by the...