Eli Wallace
Overview
Explore the profile of Eli Wallace including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
415
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Recent Articles
1.
Maciag A, Stice J, Wang B, Sharma A, Chan A, Lin K, et al.
Cancer Discov
. 2024 Dec;
15(3):578-594.
PMID: 39642212
Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct...
2.
Sharma A, Pei J, Yang Y, Dyba M, Smith B, Rabara D, et al.
J Biol Chem
. 2024 Jan;
300(2):105650.
PMID: 38237681
Individual oncogenic KRAS mutants confer distinct differences in biochemical properties and signaling for reasons that are not well understood. KRAS activity is closely coupled to protein dynamics and is regulated...
3.
Konduru S, Pan Y, Wallace E, Pfammatter J, Jones M, Maganti R
Ann Neurol
. 2021 Sep;
90(5):840-844.
PMID: 34476841
Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1 mouse model of epilepsy, daily...
4.
Filon M, Wallace E, Wright S, Douglas D, Steinberg L, Verkuilen C, et al.
Sleep
. 2020 May;
43(11).
PMID: 32369586
Study Objectives: Accumulating evidence suggests a strong association between sleep, amyloid-beta (Aβ) deposition, and Alzheimer's disease (AD). We sought to determine if (1) deficits in rest-activity rhythms and sleep are...
5.
Khan N, Schoenike B, Basu T, Grabenstatter H, Rodriguez G, Sindic C, et al.
PLoS One
. 2020 Jan;
14(12):e0226733.
PMID: 31891591
Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie...
6.
Wallace E, Wright S, Schoenike B, Roopra A, Rho J, Maganti R
Epilepsia
. 2018 Jul;
59(8):1527-1539.
PMID: 30009381
Objectives: Circadian rhythms are affected in many neurological disorders. Although sleep disturbances are known in epilepsy, data on circadian rhythm disturbances in epilepsy are sparse. Here, we examined diurnal and...
7.
Wright S, Wallace E, Hwang Y, Maganti R
Epilepsy Behav
. 2016 Jan;
55:24-9.
PMID: 26724401
This study was undertaken to describe seizure phenotypes, natural progression, sleep-wake patterns, as well as periodicity of seizures in Kcna-1 null mutant mice. These mice were implanted with epidural electroencephalography...
8.
Wallace E, Kim D, Kim K, Chen S, Braden B, Williams J, et al.
Brain Res
. 2015 May;
1615:116-128.
PMID: 25957790
Study Objective: To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. Methods: Two studies...
9.
Davies K, Humphries M, Sullivan F, von Carlowitz I, Le Huerou Y, Mohr P, et al.
Oncol Res
. 2011 Sep;
19(7):349-63.
PMID: 21936404
Chk1 is a serine/threonine kinase that plays several important roles in the cellular response to genotoxic stress. Since many current standard-of-care therapies for human cancer directly damage DNA or inhibit...
10.
Davies K, Cable P, Garrus J, Sullivan F, von Carlowitz I, Le Huerou Y, et al.
Cancer Biol Ther
. 2011 Sep;
12(9):788-96.
PMID: 21892012
Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic approach for the treatment of a wide array of...