Elaine Tuomanen
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Explore the profile of Elaine Tuomanen including associated specialties, affiliations and a list of published articles.
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31
Citations
765
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Recent Articles
1.
Davis A, Tuomanen E
J Pediatric Infect Dis Soc
. 2025 Jan;
14(1.
PMID: 39777500
In young children, pneumococcal meningitis epitomizes the paradigm of a destructive innate inflammatory response in the central nervous system: a five-alarm fire. In contrast, cell-free bacterial components reaching the fetal...
2.
Johnson C, Wilde S, Tuomanen E, Rosch J
Cell Chem Biol
. 2023 Dec;
31(2):195-206.
PMID: 38052216
Streptococcus pneumoniae is a remarkably adaptable and successful human pathogen, playing dual roles of both asymptomatic carriage in the nasopharynx and invasive disease including pneumonia, bacteremia, and meningitis. Efficacious vaccines...
3.
MacCain W, Tuomanen E
Cell Host Microbe
. 2023 May;
31(5):681-682.
PMID: 37167946
During meningitis, sensory neurons detect bacterial toxins and metabolites. Early activation of pain receptors suppresses host defense in the meninges while, later, taste receptors amplify inflammation in the spinal cord....
4.
Riegler A, Mann B, Orihuela C, Tuomanen E
Pathogens
. 2019 Oct;
8(4).
PMID: 31652741
Pneumococcal vaccine development is driven by the achievement of high activity in a single gatekeeper assay: the bacterial opsonophagocytic killing (OPK) assay. New evidence challenges the dogma that anti-capsular antibodies...
5.
Rowe H, Mann B, Iverson A, Poole A, Tuomanen E, Rosch J
Infect Immun
. 2019 Jul;
87(10).
PMID: 31308088
Acute otitis media is one of the most common childhood infections worldwide. Currently licensed vaccines against the common otopathogen target the bacterial capsular polysaccharide and confer no protection against nonencapsulated...
6.
Kietzman C, Tuomanen E
ACS Infect Dis
. 2019 Jul;
5(12):1987-1995.
PMID: 31268283
Bacterial meningitis is a medical emergency requiring highly bactericidal antibiotics to achieve cure. Many challenges exist to achieving optimal patient outcome. First, antibiotics must pass the blood brain barrier. Once...
7.
Hakim H, Dallas R, Wolf J, Tang L, Schultz-Cherry S, Darling V, et al.
Clin Infect Dis
. 2018 Mar;
67(4):541-548.
PMID: 29518185
Background: Myelosuppression-related infections remain important causes of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). Methods: By analyzing fecal samples collected at diagnosis and after each of the...
8.
Fisher B, Danziger-Isakov L, Sweet L, Munoz F, Maron G, Tuomanen E, et al.
J Pediatric Infect Dis Soc
. 2017 Nov;
7(4):275-282.
PMID: 29106589
Background: Respiratory virus infections (RVIs) pose a threat to children undergoing hematopoietic stem cell transplantation (HSCT). In this era of sensitive molecular diagnostics, the incidence and outcome of HSCT recipients...
9.
Karlsson E, Meliopoulos V, van de Velde N, Van de Velde L, Mann B, Gao G, et al.
mBio
. 2017 Sep;
8(5).
PMID: 28928207
Obesity is a risk factor for developing severe disease following influenza virus infection; however, the comorbidity of obesity and secondary bacterial infection, a serious complication of influenza virus infections, is...
10.
Mann B, Loh L, Gao G, Tuomanen E
Bio Protoc
. 2017 Jun;
6(23).
PMID: 28573167
Cell wall is a complex biopolymer on the surface of all Gram-positive bacteria. During infection, cell wall is recognized by the innate immune receptor Toll-like receptor 2 causing intense inflammation...