Ekaterina V Vinogradova
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Explore the profile of Ekaterina V Vinogradova including associated specialties, affiliations and a list of published articles.
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994
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Recent Articles
1.
Scott K, Kojima H, Ropek N, Warren C, Zhang T, Hogg S, et al.
Cell Chem Biol
. 2024 Nov;
32(1):201-218.e17.
PMID: 39591969
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide EV96 and its analogues...
2.
Scott K, Kojima H, Ropek N, Warren C, Zhang T, Hogg S, et al.
bioRxiv
. 2024 Jan;
PMID: 38187674
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide chemical probe EV96 and...
3.
Ramsey J, Shelton P, Heiss T, Olinares P, Vostal L, Soileau H, et al.
J Am Chem Soc
. 2023 Dec;
146(1):62-67.
PMID: 38134034
Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. These enzymes have key roles in diverse cellular processes, such...
4.
Liu Y, Liu S, Tomar A, Yen F, Unlu G, Ropek N, et al.
Science
. 2023 Nov;
382(6672):820-828.
PMID: 37917749
Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic functions. However, how mitochondria sense the abundance of metabolites and regulate metabolic homeostasis is not well understood. In this...
5.
Ramsey J, Shelton P, Heiss T, Olinares P, Vostal L, Soileau H, et al.
bioRxiv
. 2023 Oct;
PMID: 37808863
Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. These enzymes have key roles in diverse cellular processes, such...
6.
Tao Y, Remillard D, Vinogradova E, Yokoyama M, Banchenko S, Schwefel D, et al.
J Am Chem Soc
. 2023 Jun;
145(23):12948.
PMID: 37268298
No abstract available.
7.
Darabedian N, Ji W, Fan M, Lin S, Seo H, Vinogradova E, et al.
Nat Chem Biol
. 2023 Feb;
19(7):815-824.
PMID: 36823351
Creatine kinases (CKs) provide local ATP production in periods of elevated energetic demand, such as during rapid anabolism and growth. Thus, creatine energetics has emerged as a major metabolic liability...
8.
Tao Y, Remillard D, Vinogradova E, Yokoyama M, Banchenko S, Schwefel D, et al.
J Am Chem Soc
. 2022 Sep;
144(40):18688-18699.
PMID: 36170674
Targeted protein degradation induced by heterobifunctional compounds and molecular glues presents an exciting avenue for chemical probe and drug discovery. To date, small-molecule ligands have been discovered for only a...
9.
Vinogradova E, Cravatt B
STAR Protoc
. 2021 Apr;
2(2):100458.
PMID: 33899026
Differential amino acid reactivity with chemical probes can provide valuable information on the functionality and ligandability of proteins in native biological systems. Here, we present a quantitative, multiplexed chemical proteomic...
10.
Kuljanin M, Mitchell D, Schweppe D, Gikandi A, Nusinow D, Bulloch N, et al.
Nat Biotechnol
. 2021 Jan;
39(5):630-641.
PMID: 33398154
Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome. Here we redesigned the workflow for activity-based...