Edward W Roberts
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Explore the profile of Edward W Roberts including associated specialties, affiliations and a list of published articles.
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26
Citations
6636
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Recent Articles
1.
Samarakoon Y, Yelland T, Garcia-Gonzalez E, da Silva Justo Junior A, Mahmood M, Manoharan A, et al.
Life Sci Alliance
. 2025 Jan;
8(3).
PMID: 39814552
T-cell receptor recognition of cognate peptide-MHC leads to the formation of signalling domains and the immunological synapse. Because of the close membrane apposition, there is rapid exclusion of CD45, and...
2.
Lau V, Mead G, Varyova Z, Mazet J, Krishnan A, Roberts E, et al.
Nat Commun
. 2025 Jan;
16(1):2.
PMID: 39746898
Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, but recent studies suggest that IFNγ-resistant tumours can be sensitised for immunotherapy, yet the underlying mechanism remains...
3.
Lukoszek R, Inesta-Vaquera F, Brett N, Liang S, Hepburn L, Hughes D, et al.
Cell Rep
. 2024 Jun;
43(7):114405.
PMID: 38923463
The RNA cap methyltransferase CMTR1 methylates the first transcribed nucleotide of RNA polymerase II transcripts, impacting gene expression mechanisms, including during innate immune responses. Using mass spectrometry, we identify a...
4.
Hargrave K, Worrell J, Pirillo C, Brennan E, Masdefiol Garriga A, Gray J, et al.
Mucosal Immunol
. 2024 Jun;
17(5):843-857.
PMID: 38851589
Influenza A virus (IAV) infection leads to the formation of mucosal memory CD4 T cells that can protect the host. An in-depth understanding of the signals that shape memory cell...
5.
Cheng Z, Thompson E, Mendive-Tapia L, Scott J, Benson S, Kitamura T, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(8):e202216142.
PMID: 38515764
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon...
6.
Mahmood M, Liu E, Shergold A, Tolla E, Tait-Mulder J, Huerta-Uribe A, et al.
Nat Cancer
. 2024 Jan;
5(4):659-672.
PMID: 38286828
The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of the cancer genome, but whether these mutations...
7.
Young A, Lorimer T, Al-Khalidi S, Roberts E
Essays Biochem
. 2023 May;
67(6):929-939.
PMID: 37139854
The introduction of immunotherapy, in particular immune checkpoint inhibition, has revolutionised the treatment of a range of tumours; however, only a minority of patients respond to these therapies. Understanding the...
8.
Mahmood M, Liu E, Shergold A, Tolla E, Tait-Mulder J, Uribe A, et al.
bioRxiv
. 2023 Mar;
PMID: 36993533
The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in...
9.
Cheng Z, Thompson E, Mendive-Tapia L, Scott J, Benson S, Kitamura T, et al.
Angew Chem Int Ed Engl
. 2022 Dec;
62(8):e202216142.
PMID: 36562327
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon...
10.
Yi R, Chen E, Roberts E, Krummel M, Serwas N
PLoS One
. 2022 Aug;
17(8):e0272857.
PMID: 35976946
Effective immune responses depend on efficient antigen uptake in the periphery, transport of those antigens to, and presentation in draining lymph nodes (LNs). These processes have been studied intensively using...