Matthew F Krummel
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Explore the profile of Matthew F Krummel including associated specialties, affiliations and a list of published articles.
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166
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14732
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Recent Articles
1.
LaHue S, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, et al.
medRxiv
. 2025 Mar;
PMID: 40034792
Delirium is a neurologic syndrome characterized by inattention and cognitive impairment frequently encountered in the medically ill. Peripheral inflammation is a key trigger of delirium, but the patient-specific immune responses...
2.
Cleary S, Qiu L, Seo Y, Baluk P, Liu D, Serwas N, et al.
J Exp Med
. 2025 Feb;
222(5).
PMID: 39969509
Intravital microscopy has enabled the study of immune dynamics in the pulmonary microvasculature, but many key events remain unseen because they occur in deeper lung regions. We therefore developed a...
3.
Ray A, Hu K, Kersten K, Courau T, Kuhn N, Zaleta-Linares I, et al.
J Exp Med
. 2024 Nov;
222(1).
PMID: 39601781
CD206 is a common marker of a putative immunosuppressive "M2" state in tumor-associated macrophages (TAMs). We made a novel conditional CD206 (Mrc1) knock-in mouse to specifically visualize and/or deplete CD206+...
4.
Spottiswoode N, Tsitsiklis A, Chu V, Phan H, DeVoe C, Love C, et al.
Nat Commun
. 2024 Oct;
15(1):9339.
PMID: 39472555
Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we...
5.
Cleary S, Qiu L, Seo Y, Baluk P, Liu D, Serwas N, et al.
bioRxiv
. 2024 Sep;
PMID: 39345499
Intravital microscopy has enabled the study of immune dynamics in the pulmonary microvasculature, but many key events remain unseen because they occur in deeper lung regions. We therefore developed a...
6.
Magnen M, You R, Rao A, Davis R, Rodriguez L, Bernard O, et al.
Sci Adv
. 2024 Jul;
10(31):eadm8836.
PMID: 39083602
In the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, epithelial populations in the distal lung expressing Angiotensin-converting enzyme 2 (ACE2) are infrequent, and therefore, the model of...
7.
Kuhn N, Zaleta-Linares I, Nyberg W, Eyquem J, Krummel M
bioRxiv
. 2024 Jul;
PMID: 39071432
Discovering the role of fibroblasts residing in the tumor microenvironment (TME) requires controlled, localized perturbations because fibroblasts play critical roles in regulating immunity and tumor biology at multiple sites. Systemic...
8.
Neyton L, Patel R, Sarma A, Willmore A, Haller S, Kangelaris K, et al.
Nat Commun
. 2024 Jun;
15(1):5483.
PMID: 38942804
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood....
9.
Ray A, Hu K, Kersten K, Courau T, Kuhn N, Zaleta-Linares I, et al.
bioRxiv
. 2023 Nov;
PMID: 37961697
Tumor-associated macrophages (TAMs) are frequently categorized as being 'M1' or 'M2' polarized, even as substantial data challenges this binary modeling of macrophage cell state. One molecule consistently referenced as a...
10.
Hackney J, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, et al.
iScience
. 2023 Oct;
26(10):107813.
PMID: 37810211
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from...