Edward Kerns
Overview
Explore the profile of Edward Kerns including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
8
Citations
139
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Siramshetty V, Shah P, Kerns E, Nguyen K, Yu K, Kabir M, et al.
Sci Rep
. 2020 Nov;
10(1):20713.
PMID: 33244000
Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic stability is usually assessed in microsomal fractions and only the best compounds progress in the drug discovery process....
2.
Sun H, Nguyen K, Kerns E, Yan Z, Yu K, Shah P, et al.
Bioorg Med Chem
. 2017 Jan;
25(3):1266-1276.
PMID: 28082071
Cell membrane permeability is an important determinant for oral absorption and bioavailability of a drug molecule. An in silico model predicting drug permeability is described, which is built based on...
3.
Shah P, Kerns E, Nguyen D, Obach R, Wang A, Zakharov A, et al.
Drug Metab Dispos
. 2016 Jul;
44(10):1653-61.
PMID: 27417180
Advancement of in silico tools would be enabled by the availability of data for metabolic reaction rates and intrinsic clearance (CLint) of a diverse compound structure data set by specific...
4.
Zhang M, Gao Y, Btesh J, Kagan N, Kerns E, Samad T, et al.
J Mass Spectrom
. 2009 Dec;
45(2):167-77.
PMID: 19950120
Endocannabinoids (ECs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), modulate a number of physiological processes, including pain, appetite and emotional state. Levels of ECs are tightly controlled by enzymatic biosynthesis...
5.
Butera J, Larsen B, Hennan J, Kerns E, Di L, Alimardanov A, et al.
J Med Chem
. 2009 Jan;
52(4):908-11.
PMID: 19175320
Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. Small molecule gap-junction modifiers with improved physical properties were identified from a Zealand Pharma peptide library...
6.
McConnell O, Bach 2nd A, Balibar C, Byrne N, Cai Y, Carter G, et al.
Chirality
. 2007 Mar;
19(9):658-82.
PMID: 17390370
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential...
7.
Yu K, Di L, Kerns E, Li S, Alden P, Plumb R
Rapid Commun Mass Spectrom
. 2007 Feb;
21(6):893-902.
PMID: 17295426
We report in this paper an ultra-performance liquid chromatography/tandem mass spectrometric (UPLC(R)/MS/MS) method utilizing an ESI-APCI multimode ionization source to quantify structurally diverse analytes. Eight commercial drugs were used as...
8.
Zhang M, Kerns E, McConnell O, Sonnenberg-Reines J, Zaleska M, Jacobsen J, et al.
J Pharm Biomed Anal
. 2004 Mar;
34(2):359-68.
PMID: 15013150
A method using reverse phase liquid chromatography-tandem mass spectrometry and cassette administration was developed for in vivo brain and plasma exposure profiling to assist early CNS drug discovery programs. Three...