David K Worthylake
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Explore the profile of David K Worthylake including associated specialties, affiliations and a list of published articles.
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18
Citations
578
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Recent Articles
1.
Chandra P, Braun S, Maity S, Castorena-Gonzalez J, Kim H, Shaffer J, et al.
Viruses
. 2023 Mar;
15(3).
PMID: 36992502
Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50-60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND). Studies are uncovering the role of...
2.
Gorisse L, Li Z, Wagner C, Worthylake D, Zappacosta F, Hedman A, et al.
J Biol Chem
. 2020 Feb;
295(15):4822-4835.
PMID: 32094223
IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a scaffold protein that interacts with numerous binding partners and thereby regulates fundamental biological processes. The functions of IQGAP1 are modulated by several...
3.
Sadraeian M, Guimaraes F, Araujo A, Worthylake D, LeCour L, Pincus S
Sci Rep
. 2017 Aug;
7(1):7579.
PMID: 28790381
Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as...
4.
Liu J, Kurella V, LeCour Jr L, Vanagunas T, Worthylake D
Biochemistry
. 2016 Nov;
55(46):6433-6444.
PMID: 27798963
IQGAP1 is a multidomain scaffold protein involved in many cellular processes. We have determined the crystal structure of an N-terminal fragment spanning residues 1-191 (CHDF hereafter) that contains the entire...
5.
LeCour Jr L, Boyapati V, Liu J, Li Z, Sacks D, Worthylake D
Structure
. 2016 Aug;
24(9):1499-508.
PMID: 27524202
In signaling, Rho-family GTPases bind effector proteins and alter their behavior. Here we present the crystal structure of Cdc42·GTP bound to the GTPase-activating protein (GAP)-related domain (GRD) of IQGAP2. Four...
6.
Shen L, Macnaughtan M, Frohlich K, Cong Y, Goodwin O, Chou C, et al.
J Biol Chem
. 2015 Oct;
290(47):28141-28155.
PMID: 26438824
Secretion of effector proteins into the eukaryotic host cell is required for Chlamydia trachomatis virulence. In the infection process, Scc1 and Scc4, two chaperones of the type III secretion (T3S)...
7.
Liu J, Guidry J, Worthylake D
J Proteome Res
. 2013 Dec;
13(2):1156-66.
PMID: 24294828
Mammalian IQGAP proteins all feature multiple ∼50 amino acid sequence repeats near their N-termini, and little is known about the function of these "Repeats". We have expressed and purified the...
8.
Kim E, Buckley R, Learman S, Richard J, Parke C, Worthylake D, et al.
J Biol Chem
. 2010 Mar;
285(24):18650-61.
PMID: 20299460
Essential in mitosis, the human Kinesin-5 protein is a target for >80 classes of allosteric compounds that bind to a surface-exposed site formed by the L5 loop. Not established is...
9.
Parke C, Wojcik E, Kim S, Worthylake D
J Biol Chem
. 2009 Dec;
285(8):5859-67.
PMID: 20018897
Motor proteins couple steps in ATP binding and hydrolysis to conformational switching both in and remote from the active site. In our kinesin.AMPPPNP crystal structure, closure of the active site...
10.
Kurella V, Richard J, Parke C, Lecour Jr L, Bellamy H, Worthylake D
J Biol Chem
. 2009 Mar;
284(22):14857-65.
PMID: 19321438
IQGAP1 is a 190-kDa molecular scaffold containing several domains required for interaction with numerous proteins. One domain is homologous to Ras GTPase-activating protein (GAP) domains. However, instead of accelerating hydrolysis...