Edward A Mckenzie
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Explore the profile of Edward A Mckenzie including associated specialties, affiliations and a list of published articles.
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29
Citations
811
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Recent Articles
1.
Beaman G, Lopes F, Hofmann A, Roesch W, Promm M, Bijlsma E, et al.
Front Genet
. 2022 Jul;
13:896125.
PMID: 35812751
Urofacial (also called Ochoa) syndrome (UFS) is an autosomal recessive congenital disorder of the urinary bladder featuring voiding dysfunction and a grimace upon smiling. Biallelic variants in , coding for...
2.
Hussain H, Mckenzie E, Robinson A, Gingles N, Marston F, Warwicker J, et al.
Appl Microbiol Biotechnol
. 2021 Jun;
105(13):5657-5674.
PMID: 34180005
Bacterial expression systems remain a widely used host for recombinant protein production. However, overexpression of recombinant target proteins in bacterial systems such as Escherichia coli can result in poor solubility...
3.
Zhao T, Liu Y, Hao Y, Zhang W, Tao L, Wang D, et al.
Invest New Drugs
. 2020 Sep;
39(2):337-347.
PMID: 32978718
Legumain is a newly discovered lysosomal cysteine protease that can cleave asparagine bonds and plays crucial roles in regulating immunity and cancer metastasis. Legumain has been shown to be highly...
4.
Torres M, Akhtar S, Mckenzie E, Dickson A
Biotechnol J
. 2020 Apr;
16(2):e2000081.
PMID: 32271992
Low culture temperature enhances the cell-specific productivity of Chinese hamster ovary (CHO) cells expressing varied recombinant (r-) proteins, but the mechanisms remain unclear. Regulation of unfolded protein response (UPR) pathway...
5.
Tunnicliffe R, Hu W, Wu M, Levy C, Mould A, Mckenzie E, et al.
mBio
. 2019 Oct;
10(5).
PMID: 31641093
Serine-arginine (SR) protein kinase 1 (SRPK1) catalyzes the phosphorylation of SR proteins, which are a conserved family of splicing factors that contain a domain rich in arginine and serine repeats....
6.
Alrdahe S, Al Sadoun H, Torbica T, Mckenzie E, Bowling F, Boulton A, et al.
PLoS One
. 2019 Oct;
14(10):e0223980.
PMID: 31626638
Controlled inflammatory responses of myeloid cells recruited to wounds are essential for effective repair. In diabetes, the inflammatory response is prolonged and augmented over time, with increased myeloid cells present...
7.
Bancroft A, Levy C, Jowitt T, Hayes K, Thompson S, Mckenzie E, et al.
Nat Commun
. 2019 May;
10(1):2344.
PMID: 31138806
Infection by soil transmitted parasitic helminths, such as Trichuris spp, are ubiquitous in humans and animals but the mechanisms determining persistence of chronic infections are poorly understood. Here we show...
8.
Carballo-Amador M, Mckenzie E, Dickson A, Warwicker J
BMC Biotechnol
. 2019 May;
19(1):26.
PMID: 31072369
Background: Protein solubility characteristics are important determinants of success for recombinant proteins in relation to expression, purification, storage and administration. Escherichia coli offers a cost-efficient expression system. An important limitation,...
9.
Homans R, Khan R, Andrews M, Kjeldsen A, Natrajan L, Marsden S, et al.
Phys Chem Chem Phys
. 2018 Jun;
20(25):16949-16955.
PMID: 29873653
LOV-domains are ubiquitous photosensory proteins that are commonly re-engineered to serve as powerful and versatile fluorescent proteins and optogenetic tools. The photoactive, flavin chromophore, however, is excited using short wavelengths...
10.
Mckenzie E, Abbott W
Methods
. 2018 May;
147:40-49.
PMID: 29778647
Purified recombinant proteins are key reagents in academic and industrial research. The ability to make these proteins quickly often relies on the availability of higher eukaryotic cell hosts such as...