Paul E Brenchley
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Explore the profile of Paul E Brenchley including associated specialties, affiliations and a list of published articles.
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18
Citations
1062
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0
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Recent Articles
1.
Barbour S, Fervenza F, Induruwage D, Brenchley P, Rovin B, Hladunewich M, et al.
Clin J Am Soc Nephrol
. 2023 Jul;
18(10):1283-1293.
PMID: 37471101
Background: The 2021 Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend following anti-phospholipase A2 receptor (PLA2R) antibody levels as a marker of treatment response in membranous nephropathy; however, the optimal...
2.
Fresquet M, Lockhart-Cairns M, Rhoden S, Jowitt T, Briggs D, Baldock C, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(29):e2202209119.
PMID: 35858348
Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies targeting antigens present on glomerular podocytes, instigating a cascade leading to glomerular injury. The most prevalent circulating autoantibodies in membranous...
3.
Downie M, Gupta S, Tekman M, Cheshire C, Arora S, Licht C, et al.
Kidney Int Rep
. 2021 Jun;
6(6):1669-1676.
PMID: 34169208
Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis. Primary MN has...
4.
Fresquet M, Jowitt T, Mckenzie E, Ball M, Randles M, Lennon R, et al.
Sci Rep
. 2017 Aug;
7(1):6876.
PMID: 28761153
Phospholipase A receptor (PLAR) is a member of the mannose receptor family found in podocytes in human kidney. PLAR is the target of the autoimmune disease, membranous nephropathy, characterised by...
5.
Cattran D, Brenchley P
Kidney Int
. 2017 Jan;
91(3):566-574.
PMID: 28065518
Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009 with the identification of the glomerular-deposited...
6.
Fresquet M, Jowitt T, Gummadova J, Collins R, Ocualain R, Mckenzie E, et al.
J Am Soc Nephrol
. 2014 Oct;
26(2):302-13.
PMID: 25288605
Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin...
7.
Bech A, Hofstra J, Brenchley P, Wetzels J
Clin J Am Soc Nephrol
. 2014 Jul;
9(8):1386-92.
PMID: 25035272
Background: The optimal timing and duration of immunosuppressive therapy for idiopathic membranous nephropathy (iMN) have been debated. This study aimed to evaluate whether measuring the antibody against the phospholipase A2...
8.
Brenchley P, Poulton K, Morton M, Picton M
Transplant Rev (Orlando)
. 2014 Mar;
28(3):140-4.
PMID: 24630158
Glomerulonephritis is a significant cause of chronic kidney disease requiring renal replacement therapy. For patients receiving a transplant, it is known that specific primary pathologies such as membranous nephropathy, IgA...
9.
Lennon R, Byron A, Humphries J, Randles M, Carisey A, Murphy S, et al.
J Am Soc Nephrol
. 2014 Jan;
25(5):939-51.
PMID: 24436468
The glomerulus contains unique cellular and extracellular matrix (ECM) components, which are required for intact barrier function. Studies of the cellular components have helped to build understanding of glomerular disease;...
10.
Walkin L, Herrick S, Summers A, Brenchley P, Hoff C, Korstanje R, et al.
Fibrogenesis Tissue Repair
. 2013 Dec;
6(1):18.
PMID: 24294831
In humans, a number of genetic factors have been linked to the development of fibrosis in a variety of different organs. Seeking a wider understanding of this observation in man...