Edward A Kuhn
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Explore the profile of Edward A Kuhn including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Fischer N, Blanchette C, Segelke B, Corzett M, Chromy B, Kuhn E, et al.
PLoS One
. 2010 Jul;
5(7):e11643.
PMID: 20657844
Background: Nanolipoprotein particles (NLPs) are discoidal, nanometer-sized particles comprised of self-assembled phospholipid membranes and apolipoproteins. NLPs assembled with human apolipoproteins have been used for myriad biotechnology applications, including membrane protein...
12.
Blanchette C, Segelke B, Fischer N, Corzett M, Kuhn E, Cappuccio J, et al.
Int J Mol Sci
. 2009 Sep;
10(7):2958-2971.
PMID: 19742178
Heterogeneity is a fact that plagues the characterization and application of many self-assembled biological constructs. The importance of obtaining particle homogeneity in biological assemblies is a critical goal, as bulk...
13.
Baker S, Hopkins R, Blanchette C, Walsworth V, Sumbad R, Fischer N, et al.
J Am Chem Soc
. 2009 May;
131(22):7508-9.
PMID: 19449869
Hydrogenases constitute a promising class of enzymes for ex vivo hydrogen production. Implementation of such applications is currently hindered by oxygen sensitivity and, in the case of membrane-bound hydrogenases (MBHs),...
14.
Fischer N, Blanchette C, Chromy B, Kuhn E, Segelke B, Corzett M, et al.
Bioconjug Chem
. 2009 Feb;
20(3):460-5.
PMID: 19239247
Nanolipoprotein particles (NLPs) are nanometer-sized, discoidal particles that self-assemble from purified apolipoprotein and phospholipid. Their size and facile functionalization suggest potential application of NLPs as platforms for the presentation and...
15.
Blanchette C, Cappuccio J, Kuhn E, Segelke B, Benner W, Chromy B, et al.
Biochim Biophys Acta
. 2008 Dec;
1788(3):724-31.
PMID: 19109924
To better understand the incorporation of membrane proteins into discoidal nanolipoprotein particles (NLPs) we have used atomic force microscopy (AFM) to image and analyze NLPs assembled in the presence of...
16.
Cappuccio J, Hinz A, Kuhn E, Fletcher J, Arroyo E, Henderson P, et al.
Methods Mol Biol
. 2008 Nov;
498:273-96.
PMID: 18988032
Membrane-associated proteins and protein complexes account for approximately a third or more of the proteins in the cell (1, 2). These complexes mediate essential cellular processes; including signal transduc-tion, transport,...
17.
Cappuccio J, Blanchette C, Sulchek T, Arroyo E, Kralj J, Hinz A, et al.
Mol Cell Proteomics
. 2008 Jul;
7(11):2246-53.
PMID: 18603642
Here we demonstrate rapid production of solubilized and functional membrane protein by simultaneous cell-free expression of an apolipoprotein and a membrane protein in the presence of lipids, leading to the...
18.
Blanchette C, Law R, Benner W, Pesavento J, Cappuccio J, Walsworth V, et al.
J Lipid Res
. 2008 Apr;
49(7):1420-30.
PMID: 18403317
Self-assembly of purified apolipoproteins and phospholipids results in the formation of nanometer-sized lipoprotein complexes, referred to as nanolipoprotein particles (NLPs). These bilayer constructs are fully soluble in aqueous environments and...
19.
Chromy B, Arroyo E, Blanchette C, Bench G, Benner H, Cappuccio J, et al.
J Am Chem Soc
. 2007 Oct;
129(46):14348-54.
PMID: 17963384
Spontaneous interaction of purified apolipoproteins and phospholipids results in formation of lipoprotein particles with nanometer-sized dimensions; we refer to these assemblies as nanolipoprotein particles or NLPs. These bilayer constructs can...
20.
Boone J, McGwire K, Otteson E, DeBaca R, Kuhn E, St Jeor S
Am J Trop Med Hyg
. 2002 Nov;
67(3):310-8.
PMID: 12408674
Many researchers have speculated that infection dynamics of Sin Nombre virus are driven by density patterns of its major host, Peromyscus maniculatus. Few, if any, studies have examined this question...