Paul D Hoeprich
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Explore the profile of Paul D Hoeprich including associated specialties, affiliations and a list of published articles.
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17
Citations
367
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Recent Articles
1.
Weilhammer D, Dunkle A, Boone T, Gilmore S, Khemmani M, Peters S, et al.
Front Immunol
. 2020 Jul;
11:1264.
PMID: 32714323
Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly at critical mucosal sites such as the lung. We...
2.
Rai D, Diaz-San Segundo F, Schafer E, Burrage T, Rodriguez L, De Los Santos T, et al.
Virology
. 2016 May;
495:136-47.
PMID: 27209448
Here, we engineered two FMD viruses with histidine residues inserted into or fused to the FMDV capsid. Both 6xHis viruses exhibited growth kinetics, plaque morphologies and antigenic characteristics similar to...
3.
Coleman M, Cappuccio J, Blanchette C, Gao T, Arroyo E, Hinz A, et al.
PLoS One
. 2016 Mar;
11(3):e0150166.
PMID: 27015536
Yersinia pestis enters host cells and evades host defenses, in part, through interactions between Yersinia pestis proteins and host membranes. One such interaction is through the type III secretion system,...
4.
Fischer N, Rasley A, Corzett M, Hwang M, Hoeprich P, Blanchette C
J Am Chem Soc
. 2013 Jan;
135(6):2044-7.
PMID: 23331082
Subunit antigen-based vaccines can provide a number of important benefits over traditional vaccine candidates, such as overall safety. However, because of the inherently low immunogenicity of these antigens, methods for...
5.
Chromy B, Elsheikh M, Christensen T, Livingston D, Petersen K, Bearinger J, et al.
Future Microbiol
. 2012 Aug;
7(8):1011-20.
PMID: 22913359
Aims: Estimates suggest that the drug discovery and development processes take between 10 and 15 years, with costs ranging between US$500 million and $2 billion. A growing number of bacteria...
6.
Mayali X, Weber P, Brodie E, Mabery S, Hoeprich P, Pett-Ridge J
ISME J
. 2011 Dec;
6(6):1210-21.
PMID: 22158395
Most microorganisms remain uncultivated, and typically their ecological roles must be inferred from diversity and genomic studies. To directly measure functional roles of uncultivated microbes, we developed Chip-stable isotope probing...
7.
Fischer N, Blanchette C, Segelke B, Corzett M, Chromy B, Kuhn E, et al.
PLoS One
. 2010 Jul;
5(7):e11643.
PMID: 20657844
Background: Nanolipoprotein particles (NLPs) are discoidal, nanometer-sized particles comprised of self-assembled phospholipid membranes and apolipoproteins. NLPs assembled with human apolipoproteins have been used for myriad biotechnology applications, including membrane protein...
8.
Blanchette C, Fischer N, Corzett M, Bench G, Hoeprich P
Bioconjug Chem
. 2010 Jul;
21(7):1321-30.
PMID: 20586461
Nanolipoprotein particles (NLPs) are discoidal self-assembling membrane mimetics that have been primarily used as a platform for the solubilization and stabilization of membrane proteins. Nickel-chelating nanolipoprotein particles (NiNLPs) containing nickel-chelating...
9.
Fischer N, Infante E, Ishikawa T, Blanchette C, Bourne N, Hoeprich P, et al.
Bioconjug Chem
. 2010 Jun;
21(6):1018-22.
PMID: 20509624
Subunit antigens are attractive candidates for vaccine development, as they are safe, cost-effective, and rapidly produced. Nevertheless, subunit antigens often need to be adjuvanted and/or formulated to produce products with...
10.
Blanchette C, Segelke B, Fischer N, Corzett M, Kuhn E, Cappuccio J, et al.
Int J Mol Sci
. 2009 Sep;
10(7):2958-2971.
PMID: 19742178
Heterogeneity is a fact that plagues the characterization and application of many self-assembled biological constructs. The importance of obtaining particle homogeneity in biological assemblies is a critical goal, as bulk...