Edaise M da Silva
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Explore the profile of Edaise M da Silva including associated specialties, affiliations and a list of published articles.
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51
Citations
512
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Recent Articles
1.
Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, et al.
bioRxiv
. 2025 Mar;
PMID: 40060534
Double-strand breaks (DSBs) are toxic lesions that lead to genome instability. While canonical DSB repair pathways typically operate independently of RNA, emerging evidence suggests that RNA:DNA hybrids and transcripts near...
2.
Kudo R, Safonov A, Jones C, Moiso E, Dry J, Shao H, et al.
Cancer Cell
. 2024 Nov;
42(11):1983.
PMID: 39532066
No abstract available.
3.
Kudo R, Safonov A, Jones C, Moiso E, Dry J, Shao H, et al.
Cancer Cell
. 2024 Oct;
42(11):1919-1935.e9.
PMID: 39393354
Inhibition of CDK4/6 kinases has led to improved outcomes in breast cancer. Nevertheless, only a minority of patients experience long-term disease control. Using a large, clinically annotated cohort of patients...
4.
Rekhtman N, Tischfield S, Febres-Aldana C, Lee J, Chang J, Herzberg B, et al.
Cancer Discov
. 2024 Aug;
15(1):83-104.
PMID: 39185963
Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we performed detailed clinicopathologic, genomic,...
5.
Pareja F, Dopeso H, Wang Y, Gazzo A, Brown D, Banerjee M, et al.
Cancer Res
. 2024 Aug;
84(20):3478-3489.
PMID: 39106449
Artificial intelligence (AI) systems can improve cancer diagnosis, yet their development often relies on subjective histologic features as ground truth for training. Herein, we developed an AI model applied to...
6.
Shah O, Nasrazadani A, Foldi J, Atkinson J, Kleer C, McAuliffe P, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2322068121.
PMID: 39042692
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing...
7.
Shah O, Nasrazadani A, Foldi J, Atkinson J, Kleer C, McAuliffe P, et al.
bioRxiv
. 2024 Jun;
PMID: 38915645
Significance: MDLC displays both ductal and lobular tumor regions. Our multi-omic profiling approach revealed that these morphologically distinct tumor regions harbor distinct intrinsic subtypes and oncogenic features that may cause...
8.
Yu Y, Cao W, Cheng F, Shi Z, Han L, Yi J, et al.
Cancer Lett
. 2024 Jun;
597:217074.
PMID: 38901667
Oncogene activation through DNA amplification or overexpression is a crucial driver of cancer initiation and progression. The FOXK2 gene, located on chromosome 17q25, encodes a transcription factor with a forkhead...
9.
Gupta A, Gazzo A, Selenica P, Safonov A, Pareja F, da Silva E, et al.
bioRxiv
. 2024 May;
PMID: 38746158
Acquired genetic alterations commonly drive resistance to endocrine and targeted therapies in metastatic breast cancer , however the underlying processes engendering these diverse alterations are largely uncharacterized. To identify the...
10.
Gordhandas S, Da Cruz Paula A, Kertowidjojo E, Pareja F, Dessources K, da Silva E, et al.
Gynecol Oncol Rep
. 2024 Apr;
53:101391.
PMID: 38633674
•Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site.•The two endometrioid ECs studied acquired additional mutations during the distant metastatic...