Eckart Bindewald
Overview
Explore the profile of Eckart Bindewald including associated specialties, affiliations and a list of published articles.
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40
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1210
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Recent Articles
11.
Parlea L, Puri A, Kasprzak W, Bindewald E, Zakrevsky P, Satterwhite E, et al.
ACS Comb Sci
. 2016 Aug;
18(9):527-47.
PMID: 27509068
RNA nanostructures can be programmed to exhibit defined sizes, shapes and stoichiometries from naturally occurring or de novo designed RNA motifs. These constructs can be used as scaffolds to attach...
12.
Parlea L, Bindewald E, Sharan R, Bartlett N, Moriarty D, Oliver J, et al.
Methods
. 2016 Apr;
103:128-37.
PMID: 27090005
Designing self-assembling RNA ring structures based on known 3D structural elements connected via linker helices is a challenging task due to the immense number of motif combinations, many of which...
13.
Bindewald E, Afonin K, Viard M, Zakrevsky P, Kim T, Shapiro B
Nano Lett
. 2016 Mar;
16(3):1726-35.
PMID: 26926528
RNA is an attractive material for the creation of molecular logic gates that release programmed functionalities only in the presence of specific molecular interaction partners. Here we present HyperFold, a...
14.
Afonin K, Viard M, Tedbury P, Bindewald E, Parlea L, Howington M, et al.
Nano Lett
. 2016 Mar;
16(3):1746-53.
PMID: 26926382
Current work reports the use of single-stranded RNA toeholds of different lengths to promote the reassociation of various RNA-DNA hybrids, which results in activation of multiple split functionalities inside human...
15.
Afonin K, Bindewald E, KIreeva M, Shapiro B
Methods Enzymol
. 2015 Mar;
553:313-34.
PMID: 25726471
Recently, we developed a novel technique based on RNA/DNA hybrid reassociation that allows conditional activation of different split functionalities inside diseased cells and in vivo. We further expanded this idea...
16.
Afonin K, Kasprzak W, Bindewald E, KIreeva M, Viard M, Kashlev M, et al.
Acc Chem Res
. 2014 Apr;
47(6):1731-41.
PMID: 24758371
CONSPECTUS: The use of RNAs as scaffolds for biomedical applications has several advantages compared with other existing nanomaterials. These include (i) programmability, (ii) precise control over folding and self-assembly, (iii)...
17.
Tamim S, Vo D, Uren P, Qiao M, Bindewald E, Kasprzak W, et al.
PLoS One
. 2014 Jan;
9(1):e85591.
PMID: 24465609
miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate...
18.
McFarland A, Horner S, Jarret A, Joslyn R, Bindewald E, Shapiro B, et al.
Nat Immunol
. 2013 Nov;
15(1):72-9.
PMID: 24241692
IFNL3, which encodes interferon-λ3 (IFN-λ3), has received considerable attention in the hepatitis C virus (HCV) field, as many independent genome-wide association studies have identified a strong association between polymorphisms near...
19.
Afonin K, Desai R, Viard M, Kireeva M, Bindewald E, Case C, et al.
Nucleic Acids Res
. 2013 Nov;
42(3):2085-97.
PMID: 24194608
Control over the simultaneous delivery of different functionalities and their synchronized intracellular activation can greatly benefit the fields of RNA and DNA biomedical nanotechnologies and allow for the production of...
20.
Afonin K, Kasprzak W, Bindewald E, Puppala P, Diehl A, Hall K, et al.
Methods
. 2013 Nov;
67(2):256-65.
PMID: 24189588
The fast-developing field of RNA nanotechnology requires the adoption and development of novel and faster computational approaches to modeling and characterization of RNA-based nano-objects. We report the first application of...