Bruce A Shapiro
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Explore the profile of Bruce A Shapiro including associated specialties, affiliations and a list of published articles.
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111
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3414
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Recent Articles
1.
Olenginski L, Kasprzak W, Attionu S, Shapiro B, Dayie T
Molecules
. 2023 Feb;
28(4).
PMID: 36838792
The global burden imposed by hepatitis B virus (HBV) infection necessitates the discovery and design of novel antiviral drugs to complement existing treatments. One attractive and underexploited therapeutic target is...
2.
Kasprzak W, Shapiro B
Methods Mol Biol
. 2022 Oct;
2568:75-101.
PMID: 36227563
Recognition of the growing importance of RNA as a target for therapeutic or diagnostic ligands brings the importance of computational predictions of docking poses to such receptors to the forefront....
3.
Puri A, Ibrahim F, OReilly Beringhs A, Isemann C, Zakrevsky P, Whittenburg A, et al.
Nanomedicine
. 2022 Jun;
44:102572.
PMID: 35671983
We previously reported that hydroxylated oxime ether lipids (OELs) efficiently deliver functional Dicer substrate siRNAs (DsiRNAs) in cells. Here, we explored in vivo utility of these OELs, using OEL4 as...
4.
Olenginski L, Kasprzak W, Bergonzo C, Shapiro B, Dayie T
J Mol Biol
. 2022 May;
434(18):167633.
PMID: 35595167
Human hepatitis B virus (HBV) replication is initiated by the binding of the viral polymerase (P) to epsilon (ε), an ≈85-nucleotide (nt) cis-acting regulatory stem-loop RNA located at the 5'-end...
5.
Johnson P, Kasprzak W, Shapiro B, Simon A
Nucleic Acids Res
. 2022 Feb;
50(3):1601-1619.
PMID: 35104872
Canonical eukaryotic mRNA translation requires 5'cap recognition by initiation factor 4E (eIF4E). In contrast, many positive-strand RNA virus genomes lack a 5'cap and promote translation by non-canonical mechanisms. Among plant...
6.
Swain M, Ageeli A, Kasprzak W, Li M, Miller J, Sztuba-Solinska J, et al.
Nucleic Acids Res
. 2021 Dec;
49(22):13179-13193.
PMID: 34871450
Cellular and virus-coded long non-coding (lnc) RNAs support multiple roles related to biological and pathological processes. Several lncRNAs sequester their 3' termini to evade cellular degradation machinery, thereby supporting disease...
7.
Gupta K, Puri A, Shapiro B
DNA RNA Nanotechnol
. 2021 Jul;
4(1):1-20.
PMID: 34322587
RNA interference (RNAi) has been regarded as a vital asset in the field of therapeutics as it has the capability to silence various disease causing genes including those that cause...
8.
Dao B, Viard M, Martins A, Kasprzak W, Shapiro B, Afonin K
DNA RNA Nanotechnol
. 2021 Jul;
2(1):1-12.
PMID: 34322586
Proteins are considered to be the key players in structure, function, and metabolic regulation of our bodies. The mechanisms used in conventional therapies often rely on inhibition of proteins with...
9.
Afonin K, Lindsay B, Shapiro B
DNA RNA Nanotechnol
. 2021 Jul;
1(1):1-15.
PMID: 34322585
Nucleic acids have emerged as an extremely promising platform for nanotechnological applications because of their unique biochemical properties and functions. RNA, in particular, is characterized by relatively high thermal stability,...
10.
Halman J, Satterwhite E, Smollett J, Bindewald E, Parlea L, Viard M, et al.
RNA Dis
. 2021 Jul;
4.
PMID: 34307841
The targeted and conditional activation of pharmaceuticals is an increasingly important feature in modern personalized medicine. Nucleic acid nanoparticles show tremendous potential in this exploit due to their programmability and...