E R Pfefferkorn
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Explore the profile of E R Pfefferkorn including associated specialties, affiliations and a list of published articles.
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75
Citations
1956
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Recent Articles
1.
Pfefferkorn E, Bzik D, Honsinger C
Exp Parasitol
. 2002 Mar;
99(4):235-43.
PMID: 11888251
In contrast to the cytocidal effect of 6-thiopurines on mammalian cells, the action of 6-thioxanthine on Toxoplasma gondii was only parasitostatic. 6-Thioxanthine was a substrate of the parasite's hypoxanthine-guanine phosphoribosyltransferase....
2.
Piper J, Johnson C, KRAUTH C, Carter R, Hosmer C, Queener S, et al.
J Med Chem
. 1996 Mar;
39(6):1271-80.
PMID: 8632434
2,4-Diaminopteridines (21 compounds) and 2,4-diamino-5-methyl-5-deazapteridines (34 compounds) along with three 2,4-diamino-5-unsubstituted-5-deazapteridines and four 2,4-diaminoquinazolines, each with an aryl groups attached to the 6-position of the heterocyclic moiety through a two-atom...
3.
Pfefferkorn E, Borotz S
Exp Parasitol
. 1994 Nov;
79(3):374-82.
PMID: 7957757
6-Thioxanthine caused 50% inhibition of the growth of Toxoplasma gondii in human fibroblasts at a concentration of 5 micrograms/ml. A mutant induced by treatment with ethylnitrosourea (ThxR-1) was 20-fold more...
4.
Gupta S, Carlin J, Pyati P, Dai W, Pfefferkorn E, Murphy Jr M
Infect Immun
. 1994 Jun;
62(6):2277-84.
PMID: 8188349
Studies were carried out to evaluate the proposed role of indoleamine 2,3-dioxygenase (INDO) induction in the antimicrobial and antiproliferative effects of gamma interferon (IFN-gamma) in human fibroblasts. The INDO cDNA...
5.
Pfefferkorn E, Borotz S
Antimicrob Agents Chemother
. 1994 Jan;
38(1):31-7.
PMID: 8141576
Azithromycin and spiramycin markedly inhibited the growth of Toxoplasma gondii in cultured human fibroblasts. However, 3 days of treatment were required to reveal their full antitoxoplasma activity. This delayed onset...
6.
Ricketts A, Pfefferkorn E
Antimicrob Agents Chemother
. 1993 Nov;
37(11):2358-63.
PMID: 8285619
Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. Of 13 anticoccidial drugs tested, 9 had...
7.
Sibley L, Pfefferkorn E, Boothroyd J
Parasitol Today
. 1993 Oct;
9(10):392-5.
PMID: 15463677
The protozoan parasite Toxoplasma gondii has recently emerged as an important opportunistic pathogen in humans. Toxoplasma also shares a number of biological features with Plasmodium and Eimeria, which are important...
8.
Pfefferkorn E, Borotz S, Nothnagel R
J Parasitol
. 1993 Aug;
79(4):559-64.
PMID: 8331476
Mutants of Toxoplasma gondii resistant to drugs that appear to affect the mitochondrial bc1 complex were isolated with the aid of mutagenesis with ethylnitrosourea. Mutant DeqR-1 was > 1,000-fold more...
9.
Piper J, Johnson C, Hosmer C, Carter R, Pfefferkorn E, Borotz S, et al.
Adv Exp Med Biol
. 1993 Jan;
338:429-33.
PMID: 8304151
No abstract available.
10.
Sibley L, LeBlanc A, Pfefferkorn E, Boothroyd J
Genetics
. 1992 Dec;
132(4):1003-15.
PMID: 1360931
We have constructed a genetic linkage map for the parasitic protozoan, Toxoplasma gondii, using randomly selected low copy number DNA markers that define restriction fragment length polymorphisms (RFLPs). The inheritance...