L D Sibley
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Explore the profile of L D Sibley including associated specialties, affiliations and a list of published articles.
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84
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5448
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Recent Articles
1.
Cabral G, Wang Z, Sibley L, DaMatta R
Front Microbiol
. 2018 Sep;
9:1936.
PMID: 30177926
, the causative agent of toxoplasmosis, is a widespread intracellular parasite able to infect virtually any nucleated cell. infection of activated macrophages inhibits nitric oxide (NO) production; however, parasite effectors...
2.
Dubey J, Van Why K, Verma S, Choudhary S, Kwok O, Khan A, et al.
Vet Parasitol
. 2013 Dec;
200(1-2):74-84.
PMID: 24332401
Recent studies indicated the predominance of Toxoplasma gondii haplogroup 12 in wildlife in the USA. However, still little is known of the genetic diversity of this parasite circulating in wildlife....
3.
Khan A, Fux B, Su C, Dubey J, Darde M, Ajioka J, et al.
Proc Natl Acad Sci U S A
. 2007 Sep;
104(37):14872-7.
PMID: 17804804
Toxoplasma gondii is a highly prevalent protozoan parasite that infects a wide range of animals and threatens human health by contaminating food and water. A markedly limited number of clonal...
4.
Saeij J, Boyle J, Coller S, Taylor S, Sibley L, Brooke-Powell E, et al.
Science
. 2006 Dec;
314(5806):1780-3.
PMID: 17170306
The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the...
5.
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii
Taylor S, Barragan A, Su C, Fux B, Fentress S, Tang K, et al.
Science
. 2006 Dec;
314(5806):1776-80.
PMID: 17170305
Toxoplasma gondii strains differ dramatically in virulence despite being genetically very similar. Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence...
6.
Sibley L
Science
. 2004 Apr;
304(5668):248-53.
PMID: 15073368
Intracellular parasites use various strategies to invade cells and to subvert cellular signaling pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to exploit intracellular...
7.
Wetzel D, Hakansson S, Hu K, Roos D, Sibley L
Mol Biol Cell
. 2003 Feb;
14(2):396-406.
PMID: 12589042
Host cell entry by Toxoplasma gondii depends critically on actin filaments in the parasite, yet paradoxically, its actin is almost exclusively monomeric. In contrast to the absence of stable filaments...
8.
Su C, Evans D, Cole R, Kissinger J, Ajioka J, Sibley L
Science
. 2003 Jan;
299(5605):414-6.
PMID: 12532022
The global predominance of three clonal Toxoplasma gondii lineages suggests that they are endowed with an exceptional trait responsible for their current parasitism of nearly all warm-blooded vertebrates. Genetic polymorphism...
9.
Dubey J, Barr B, Barta J, Bjerkas I, Bjorkman C, Blagburn B, et al.
Int J Parasitol
. 2002 Jun;
32(8):929-46.
PMID: 12076623
Neospora caninum is a protozoan parasite of animals, which before 1984 was misidentified as Toxoplasma gondii. Infection by this parasite is a major cause of abortion in cattle and causes...
10.
Mordue D, Monroy F, La Regina M, Dinarello C, Sibley L
J Immunol
. 2001 Oct;
167(8):4574-84.
PMID: 11591786
Virulence in Toxoplasma gondii is strongly influenced by the genotype of the parasite. Type I strains uniformly cause rapid death in mice regardless of the host genotype or the challenge...